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The flexible fixed-sequence testing method allows for more effective evaluation of multiple goals in a clinical trial while controlling the risk of false positives.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

High androgen levels in Chinese women with PCOS are linked to a higher risk of diabetes and obesity.

Melatonin may reduce skin damage caused by X-rays in rats.

South Asian women with PCOS experience more psychological distress and have a poorer quality of life, especially in social relationships, with hirsutism affecting them more than obesity.

Early detection and treatment of PCOS in teenagers is important to manage symptoms and prevent severe issues.

Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

Long-term finasteride use doesn't change bone density or metabolism.

Panax ginseng is generally safe with mild side effects and may have health benefits, but more research is needed.

Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Melatonin improved mental health and metabolism in women with PCOS.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

Women with PCOS have lower ghrelin levels and a weaker response to sugar, which might affect their feeling of fullness and lead to overeating.

Kids with alopecia areata may experience more stress but not necessarily feel more anxious or depressed than others.

Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

Women with PCOS are more likely to have insulin resistance and obesity, especially those with the most severe type I PCOS.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Improved Finasteride delivery for hair loss treatment.

Hair loss in women often doesn't follow a pattern, isn't linked to age, may be genetic, and can be related to thyroid issues or other health factors.

Some plant-derived compounds may help with hormonal conditions, but more research is needed to confirm their effectiveness.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.