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In a rat scalp expansion model, this study found that activating autophagy with rapamycin enhanced skin regeneration during tissue expansion by increasing expanded skin area, epidermis and dermis thicknesses, cell proliferation, angiogenesis, and other regenerative factors, whereas blocking autophagy reversed these effects.

This study suggests that inhibiting testosterone via the 5α-reductase pathway might help alleviate sleep-related breathing instability in certain central sleep apnea populations.

This study found that oral finasteride 1 mg/day promotes hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss over two years.

This study found that corticosterone promotes neurosteroid synthesis in hippocampal neurons, which can lead to ethanol-mediated synaptic dysfunction even at moderate ethanol levels, potentially contributing to stress-related cognitive impairment from alcohol.

Finasteride can help with hair loss but may cause mental health issues like depression and anxiety.

This study found that saponin derivatives from P chinensis may effectively block CRH receptor function and could be used to treat stress-induced hair loss.

This review highlights that bicalutamide, a non-steroidal antiandrogen used in prostate cancer treatment, is mainly effective through its (R)-enantiomer and emphasizes the need to monitor its adverse effects despite its targeted antiandrogenic action.

This review discusses the mechanisms, uses, and side effects of conventional synthetic DMARDs, particularly methotrexate, for rheumatoid arthritis, but reports no new clinical findings.

This opinion article reviews various pathways through which onabotulinumtoxinA might work in medical treatments, highlighting applications beyond muscle paralysis, including pain inhibition and potential effects on hair loss and cancer cell apoptosis.

This review explores the promising but varied effectiveness of tyrosine kinase inhibitors for treating different skin diseases, indicating their potential in dermatology while acknowledging the need for more evidence.

This case study identified non-criteria antiphospholipid syndrome as a potential underlying cause of Budd-Chiari syndrome in a patient, emphasizing the need for its consideration, especially in cases with multiple thromboemboli and thrombocytopenia.

This study found that the opioid system, particularly via the delta opioid receptor, broadly regulates cutaneous mechanosensation, including touch, and suggests targeting this receptor could alleviate injury-induced mechanical hypersensitivity.

This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.

This paper discusses spironolactone as a potential off-label treatment for female pattern hair loss, noting its ability to halt hair loss progression and induce partial regrowth in a significant number of women but reports no new clinical results.

The researchers reported that topical application of small-molecule Wnt inhibitors significantly reduced fibrosis and promoted regenerative wound healing in mice.

This study reported that disrupting ephrin-Eph interactions in adult mouse skin doubled cell proliferation in the hair follicle and epidermis, suggesting ephrins as negative regulators of proliferation.

This study found enhanced remyelination in the corpus callosum of late pregnant rats compared to virgin and postpartum rats, suggesting a pregnancy-associated promyelinating effect mediated, in part, by the GABA A receptor system.

This study found that anti-CD44 treatment inhibited leukocyte migration in alopecia areata and eczema, suggesting targeted therapies could enhance contact sensitizer treatment for alopecia areata.

This study found that MYC and FGF pathways are crucial for hair cell regeneration in chick and zebrafish models, suggesting potential targets for promoting hair cell regeneration in mammals.

In this study, researchers found that after reducing GABAergic inhibition in rats' auditory midbrain, the brain quickly compensates by increasing local neurosteroid synthesis to maintain balance in neural circuits.

This study reports that cimetidine treatment resulted in good to excellent hair regrowth in 70% of the small group of women with androgenetic alopecia, with no major side effects observed.

This study identified a small molecule that activates GLI1, suppressing neuroblastoma cell growth, which may aid in developing new treatments for high-risk neuroblastoma cases.

This study did not find any significant effects of estradiol or its antagonists on hair growth in two common mouse strains, challenging previous results reported by Oh and Smart.

This review discusses the established efficacy and safety of finasteride and dutasteride for benign prostatic hyperplasia, their use with alpha adrenergic blockers, and the potential unclear role in cancer prevention.

This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.

This study found that endothelin produced by hair follicle progenitors activates contractions in dermal sheath cells, facilitating hair follicle regression in the growth cycle.

This study found that resistance to azithromycin in multiple myeloma cells was associated with activation of the Hedgehog signaling pathway and suggests that targeting this pathway could help improve drug resistance.

Harris et al. describe a new mouse model for vitiligo, where interfollicular melanocytes are retained and melanocyte-targeting immune responses are simulated, aiding the development of immunomodulatory therapies.