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Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Probiotic bacteria improved skin and hair health in aged mice.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Researchers found that hair shedding happens mostly when new hair is growing and involves a unique process.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

A genetic region near the PAX1 gene is linked to a higher risk of scoliosis in females.

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.