This study found that bitter melon leaf extract, particularly at a 10% concentration, promoted hair growth in male rabbits, outperforming the effect of a 2% minoxidil solution.
23 citations
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November 2015 in “Phytotherapy Research” This study found that cucurbitacin I from bitter melon most effectively inhibited the growth of lung cancer cells and promoted hair cell growth in cell cultures.
3 citations
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August 2019 in “Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan” In this study on New Zealand white rabbits, the researchers reported that a hair tonic formula combining bitter melon leaf and carrot extracts resulted in optimal hair growth, particularly at a 3:1 ratio and a concentration of 3%, without causing irritation.
1 citations
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April 2022 in “Applied sciences” This study reports the development of a microemulsion using Momordica charantia extract, which demonstrated strong antioxidant and 5α-reductase inhibitory activity, potentially aiding hair loss management. The microemulsion was stable over 12 weeks, suggesting its future potential for cosmetic or pharmacological applications.
1 citations
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December 2021 in “Jurnal Insan Farmasi Indonesia” This study found that pomade containing 12% ethanol extract of Momordica charantia L. leaves promoted hair growth more effectively in male white rats compared to lower concentrations and a control.
December 2025 in “Zona Kebidanan Program Studi Kebidanan Universitas Batam” In this study, postpartum mothers using bitter melon fruit masks reported a significant reduction in hair loss, with 26 out of 30 participants experiencing improvements, as analyzed by the Wilcoxon test (p < 0.001).
July 2022 in “Forte Journal” In this study, researchers tested hair tonic formulations with varying concentrations of bitter melon extract and found that higher concentrations enhanced hair growth in rabbits, with the 15% extract showing the greatest effect without causing skin irritation.
March 2021 in “Egyptian Journal of Chemistry” In this study, researchers analyzed a herbal shampoo containing Momordica charantia extract and Hibiscus Rosa-Sinensis, noting it could support collagen development and hair growth. The shampoo, tailored to various hair and scalp conditions, was confirmed free of certain harmful heavy metals.
This study concluded that bitter melon leaf ethanol extract can be effectively formulated into a shampoo that meets quality standards and promotes rabbit hair growth.
This study found that a hair mask made from bitter gourd effectively reduced hair loss and dandruff among participants, though the authors note the need for clinical trials and durability tests for further validation.
10 citations
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April 2019 in “Environmental Science and Pollution Research” In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits.
January 2026 in “American Journal of Translational Research” In this study, the combination of metoprolol and spironolactone in patients with coronary heart disease and heart failure significantly improved cardiac function and reduced inflammation and oxidative stress markers compared to spironolactone alone, with better clinical efficacy and fewer adverse effects.
10 citations
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March 2014 in “Scandinavian journal of clinical and laboratory investigation” This study found that MDA-modified DNA may contribute to immune responses in alopecia areata patients by creating neo-epitopes, providing new insights into the condition's immunological mechanisms.
1 citations
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September 2024 in “Acta Scientiarum Polonorum Hortorum Cultus” This study found that spraying melon plants with 0.1 mg·L–1 molybdenum significantly improved growth, photosynthetic characteristics, carbohydrate metabolism, and fruit quality under high-temperature stress, boosting fruit weight by 27.9% and yield per plant by 20.1% compared to untreated controls.
58 citations
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June 2012 in “Journal of Alternative and Complementary Medicine” This review analyzes the traditional Iranian medicine uses of Citrullus colocynthis and compares them with modern phytotherapy findings, reporting no new clinical results but noting safety concerns and dosage considerations.
April 2022 in “Journal of applied science and environmental management” This study found that Aframomum melegueta seed extract improved wound healing in albino rats, with treated groups showing smaller wound sizes and formation of new tissues compared to controls.
March 2021 in “International journal for research in applied science and engineering technology” In this study, researchers explored the use of natural herbal hair dyes made from tannin-producing plants like henna and pomegranate, reporting that these dyes can permanently color hair without causing damage or irritation, unlike synthetic dyes.
February 2018 in “Egyptian Journal of Radiation Sciences and Applications” This study observed that Egyptian patients with discoid lupus erythematosus have significantly lower serum vitamin D3 and antioxidant levels compared to healthy controls, suggesting potential benefits of vitamin D3 and antioxidant supplementation.
7 citations
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January 2019 in “Brazilian Journal of Pharmaceutical Sciences” This study found that Adiantum capillus-veneris extract exhibited significant antidepressant and anti-anxiety effects in rats, likely due to its antioxidant and anti-inflammatory properties.
14 citations
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March 2023 in “Scientific Reports” This study found that in women with polycystic ovary syndrome, PCOS phenotype and oxidative stress markers were significantly related to free androgen index levels, but insulin resistance was not.
12 citations
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September 2018 in “International Journal of Cosmetic Science” This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.
1 citations
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March 2015 in “Journal of the European Academy of Dermatology and Venereology” This letter to the editor shares a case study of lentiginous melanoma that appears clinically malignant but histopathologically benign, involving the BRAFV600R mutation.
September 2025 in “Turkish Journal of Dermatology” This study found that children with alopecia areata had higher levels of oxidative stress markers but showed no significant differences in depression and suicide tendencies compared to healthy peers.
October 2025 in “Scientific Reports” This study found that the extracts of Serenoa repens, when evaluated through chemical, biological, and in silico methods, demonstrated anti-inflammatory, pro-apoptotic, and anti-androgenic activities against prostate cancer cell lines, suggesting potential therapeutic benefits and directing future pharmaceutical development.
29 citations
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March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
June 2025 in “Journal of Education Health and Sport” This review highlights that while finasteride and minoxidil effectively treat androgenetic alopecia, emerging options like dutasteride, mesotherapy, androgen blockers, and red LED therapy show promising results, especially when used in combination, though further research is needed for standardization and safety confirmation.
36 citations
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May 2025 in “Antioxidants” This study found that lipid peroxidation products play a clear role in the pathogenesis of skin diseases like psoriasis, vitiligo, and alopecia, but their role in diseases like melanoma and atopic dermatitis remains unclear.
12 citations
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September 2020 in “JAMA Dermatology” This article reviews the clinical features and associated medical diagnoses of pityriasis rubra pilaris, noting incomplete information on disease prevalence and related conditions but offering no new clinical findings.
8 citations
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October 2022 in “Cold Spring Harbor perspectives in biology” The document concludes that better understanding the wound microbiome can improve chronic wound care by preserving helpful bacteria and targeting harmful ones.
1 citations
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January 2017 in “Social Science Research Network” This paper suggests that to better protect traditional and indigenous knowledge, TKDL should expand its database or establish a separate confidential resource for indigenous, tribal, and nomadic communities.