36 citations,
October 2008 in “European journal of paediatric neurology” Valproic acid treatment may cause temporary hair loss due to reduced zinc and biotinidase levels, which tend to normalize after 6 months.
21 citations,
June 2011 in “Journal of child neurology” Valproic acid and carbamazepine do not change biotin or biotinidase levels but may lower zinc levels, still within normal range.
8 citations,
December 2019 in “Molecular genetics and metabolism reports” Some children in Malaysia with symptoms have either profound or partial biotinidase deficiency, and early testing and treatment are important.
43 citations,
April 2005 in “The Journal of Dermatology” Biotin supplements improved skin and hair in a biotin-deficient infant on amino acid formula.
1 citations,
February 2022 in “Biological Trace Element Research” The combination of Arginine Silicate Inositol Complex and a new form of Biotin improved hair and nail growth in rats.
78 citations,
January 2017 in “Skin appendage disorders” Biotin supplements may improve hair and nail growth in people with certain deficiencies or conditions, but there's not enough evidence to recommend it for healthy individuals.
40 citations,
August 2018 in “Skin appendage disorders” Some alternative treatments for hair loss might work, but more research is needed.
25 citations,
January 2017 in “International Journal of Trichology” Most Indian people with hair loss in the study lacked nutrients, especially iron.
11 citations,
January 2018 in “International journal of trichology” Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
86 citations,
January 1990 in “The Journal of Pediatrics” Children with partial biotinidase deficiency are healthy at birth but may develop symptoms that improve with biotin therapy.
20 citations,
December 2011 in “Journal of inherited metabolic disease” Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.
10 citations,
April 2020 in “Clinics in Dermatology” Biotin supplements improved skin and hair problems in a girl with biotinidase deficiency.
22 citations,
September 2008 in “Brain & development” Biotin supplements increased biotin levels but did not significantly prevent hair loss in rats on valproic acid.
73 citations,
October 2001 in “Epilepsia” Children taking higher doses of valproic acid had lower biotinidase activity, which may lead to biotin deficiency, but biotin supplements could help.
September 2009 in “European journal of paediatric neurology” Biotin supplements did not significantly reduce hair loss in rats on valproic acid.
29 citations,
July 1996 in “Acta Paediatrica” Biotin should be added to Japanese amino acid formula to prevent deficiency.
15 citations,
May 2006 in “Brain & development” Valproic acid may cause hair loss by reducing biotinidase enzyme activity in rats.
16 citations,
May 2009 in “Journal of child neurology” Valproic acid does not change biotinidase enzyme activity in children's blood.
166 citations,
November 2008 in “Expert Review of Endocrinology & Metabolism” Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.
71 citations,
January 2016 in “International Journal of Trichology” Biotin deficiency is not a major cause of hair loss in women, so biotin supplements are not likely to be an effective hair loss treatment.
3 citations,
January 2021 in “Molecular genetics & genomic medicine” The study found two new mutations in a Chinese patient with severe biotinidase deficiency.
Older people tend to have higher biotin levels, which are weakly linked to certain blood components and negatively linked to triglycerides; biotin should be checked in patients with high triglycerides or medication-related skin issues, and only supplemented if deficient. Vitamin D and folate deficiencies are linked to specific skin conditions.
11 citations,
February 2019 in “Journal of Cosmetic Dermatology” Low zinc and biotin levels linked to male hair loss; supplements may help.
September 1998 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Hair changes could indicate neurological diseases and help monitor treatment.
57 citations,
February 2018 in “Journal of the American Academy of Dermatology” Biotin supplements are not proven to improve hair or nails and may interfere with medical tests.
2 citations,
January 2013 in “Elsevier eBooks” The document explains the genetic causes and characteristics of inherited hair disorders.
August 2023 in “Natural Resources for Human Health” Vegetarians should take B vitamin supplements to avoid health issues.
6 citations,
April 2019 in “Nutrients” Biotin is important for keeping zinc levels balanced in the skin and its lack can cause hair loss.
January 2021 in “Scandinavian journal of clinical and laboratory investigation” The document describes a way to measure biotin in blood to prevent wrong test results in hormone level testing.
10 citations,
September 2013 in “Nutrition” The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.