October 2022 in “Research, Society and Development” This review highlights that while vitamin and mineral supplementation shows limited impact on hair loss treatment, deficiencies in iron, zinc, and vitamin D are common among patients with telogen effluvium.
January 2018 in “Journal of Diabetic Association Medical College.” This case study reports a two and a half-month-old with biotinidase deficiency who showed rapid seizure improvement with biotin treatment after presenting with convulsions and neurological symptoms.
2 citations
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July 2021 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This review discusses hair shaft disorders, noting the lack of specific treatments and recommending general care practices to prevent hair damage, with some improvement possible during puberty or with treatments like minoxidil.
December 2025 in “International Journal of Innovative Technologies in Social Science” This narrative review assesses evidence on the role of oral supplements in reducing common side effects caused by isotretinoin treatment for acne vulgaris, with the aim of providing guidance for enhancing treatment tolerability.
July 2025 in “Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria” This study reviewed various supplements for treating androgenetic alopecia and found that Serenoa repens shows the strongest evidence for use as a single treatment, while ketoconazole may help as an adjunct. Other supplements like zinc, vitamin D, and biotina are not recommended unless deficiencies exist.
March 2024 in “Clinical, cosmetic and investigational dermatology” This study found that in healthy adult women, a collagen and antioxidant-rich treatment significantly improved skin elasticity, hydration, texture, and reduced wrinkles and hair fall over 56 days compared to a placebo, indicating its efficacy and safety.
September 1983 in “Journal of The American Academy of Dermatology” Experts discussed hair care, genetic hair defects, hair loss treatments, nail surgery, lupus treatments, skin infections, and cosmetic allergies.
86 citations
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January 1990 in “The Journal of Pediatrics” This study suggests that biotin therapy may be beneficial for individuals with partial biotinidase deficiency, as some developed symptoms later, which resolved with treatment.
22 citations
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September 2008 in “Brain & development” In this study on rats, valproic acid was associated with reduced biotinidase enzyme activity and higher alopecia rates, but biotin supplementation did not significantly affect alopecia occurrence.
1 citations
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July 2017 in “Skin appendage disorders” A 9-year-old Hispanic girl has Uncombable Hair Syndrome, which may improve with age and biotin treatment.
August 2021 in “Benha Journal of Applied Sciences” This study found that biotin supplementation significantly improved hair loss in telegon effluvium patients with low serum biotin levels.
August 2018 in “Journal of the American Academy of Dermatology” This review discusses the evidence for biotin supplementation in treating hair loss, concluding that its benefits are poorly supported by data and advising against routine use without more compelling future trials.
88 citations
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June 2009 in “Cleveland Clinic Journal of Medicine” This article reviews various causes of diffuse hair loss, highlighting the importance of identifying triggers through thorough examination for effective treatment and emphasizing patient education in management; it reports no new clinical findings.
2 citations
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January 2019 in “International Journal of Medicine in Developing Countries” This review discusses telogen effluvium as a common cause of diffuse hair loss and reports no new clinical results, noting diagnostic and treatment challenges.
1 citations
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September 1993 in “Archives of Disease in Childhood” This article discusses the importance of considering biotinidase deficiency in differential diagnosis for patients with certain neurological and dermatological symptoms, as timely treatment with biotin is crucial to prevent severe consequences.
June 2026 in “Clinical Case Reports” This case report describes a 4-month-old child with symptoms suggesting multiple carboxylase deficiency, which responded well to biotin therapy, highlighting the importance of early diagnosis and treatment to prevent serious health issues in infants with similar unexplained metabolic acidosis and symptoms.
September 2023 in “IP Journal of Nutrition, Metabolism and Health Science/IP Journal of Nutrition Metabolism and Health Science” This study observed that hirsutism, alopecia, and acne are the most common androgenic symptoms in women with PCOS, with treatments including biotin, minoxidil, and over-the-counter acne medications.
48 citations
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October 2011 in “Sports Medicine” This review covers dermatological conditions experienced by ice-skating athletes due to cold exposure, infections, and inflammation, providing no new clinical findings and emphasizing diagnosis and treatment strategies.
10 citations
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July 2018 in “Our Dermatology Online” This research reviewed literature to evaluate the role of micronutrients in hair loss and hair growth, examining normal nutrient levels, their role in the hair follicle cycle, and their use in treatments, with data drawn from 92 peer-reviewed articles and reputable health organizations.
November 2025 in “International Journal of Apllied Mathematics” In this study, the derivation of certain topological indices was used to represent the molecular structure of drugs for alopecia treatment, like Minoxidil and Finasteride, which may support medication investigations, especially in resource-limited settings.
This study found that in individuals with alopecia, scalp microbial diversity decreased while Cutibacterium acnes abundance increased, and that treating Cutibacterium acnes-infected mice with Lactobacillus plantarum L30 improved hair follicle health and hair growth, suggesting a potential new treatment pathway for alopecia.
January 2024 in “Revista del Centro Dermatológico Pascua” In this case report, a 24-year-old male with acquired distal trichorrhexis nodosa showed significant improvement after avoiding harmful hair treatments and using a repair shampoo alongside biotin and zinc supplements.
June 2023 in “JAAD international” This report highlights that 49.4% of U.S. patients with skin issues use complementary and alternative medicine (CAM), with 6% leveraging it specifically for their skin conditions, including treatments like herbal, vitamin, and mineral supplementation for alopecia.
August 2022 in “Journal of the American Academy of Dermatology” This review discusses the risk factors, clinical presentation, diagnosis, and management of dermatoses linked to B-complex vitamin deficiencies, including biotin, but does not address risks from over-supplementation.
April 2021 in “Libyan journal of medical sciences” This case report documented alopecia as a rare complication of SARS-CoV-2 infection in a 33-year-old woman, with hair loss improving after treatment.
May 2015 in “Cancer research” This study found that persistent significant alopecia was a common side effect following FEC-docetaxel chemotherapy, with a 33.4% global incidence, highlighting the need for awareness and potential preventative measures like cooling caps during treatment.
January 2014 in “Journal of Pigmentary Disorders” This review discusses age-related and environmental factors affecting scalp hair changes in women, highlighting diagnostic complexities and ongoing research into targeted treatments, without reporting new clinical results.
April 2012 in “Journal of evolution of medical and dental sciences” This report describes a rare case of papular atrichia in a 4-year-old girl, highlighting the absence of effective treatment to stimulate hair growth for this condition.
101 citations
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July 1985 in “Journal of the American Academy of Dermatology” In this study, oral biotin improved hair growth, strength, and combability in a child with uncombable hair syndrome, while hair in two others slowly improved without biotin.
78 citations
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January 2017 in “Skin appendage disorders” This review discusses the use of biotin for hair and nail growth, noting clinical improvement in cases with existing pathologies, but concludes there is insufficient evidence supporting its benefits for healthy individuals.