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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Finasteride may improve prostate cancer treatment outcomes.

Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.

Over 150 new molecules with biological activities were found in traditional herbal medicines, some with potential for new drug development.

Genetic defects in androgen production are linked to male developmental disorders and are improving treatment understanding.

Blocking allopregnanolone production in mice makes them more anxious after stress, but this can be reversed with a drug that mimics allopregnanolone.

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

Noncoding dsRNA helps produce exosomes that aid in skin regeneration.

Gene mutations can cause problems in male genital development.

Anti-androgen drugs can treat conditions like prostate cancer and male pattern baldness by blocking effects of testosterone and DHT.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

Melatonin helps broccoli roots produce anti-cancer compounds by controlling nitric oxide and hydrogen peroxide levels.

Polyamines are important in deciding hair follicle stem cell behavior, affecting hair growth and loss.

Altering maternal cortisol during pregnancy can improve wool growth in Merino sheep.

Frontal Fibrosing Alopecia involves disrupted cholesterol pathways, fibrosis, and increased mast cells.

Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.

Minoxidil boosts hair growth by undergoing a process in hair follicles and certain skin cells, and by increasing the production of compounds essential for hair growth and maintenance.

Resveratrol activates the Nrf2 pathway in human skin, significantly increasing the production and distribution of the antioxidant glutathione.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Ketoconazole cured about 70% of cutaneous leishmaniasis cases caused by Leishmania major.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Without keratin 10, there's more growth and development of oil-producing skin cells.

Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.