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research Regulatory network of ginsenoside biosynthesis under Ro stress in the hairy roots of Panax ginseng revealed by RNA sequencing
Ro stress hindered ginseng root growth and ginsenoside production, but increased certain hormones and affected gene regulation related to plant growth and stress responses.
research Identification and Characterization of Two Se6OMTs from Stephania epigaea Offer Novel Insights into the Biosynthetic Pathway of Cepharanthine
In this study, researchers identified specific Se6OMT enzymes in *S. epigaea* involved in the cepharanthine biosynthetic pathway, providing insights into their substrate promiscuity and essential genetic components for metabolic engineering and synthetic biology applications of cepharanthine production.
research Glucoraphanin and sulforaphane biosynthesis by melatonin mediating nitric oxide in hairy roots of broccoli (Brassica oleracea L. var. italica Planch): insights from transcriptome data
Melatonin helps broccoli roots produce anti-cancer compounds by controlling nitric oxide and hydrogen peroxide levels.
research Uncovering the biosynthetic pathway of bioactive compounds from Eclipta prostrata (L.) L. hairy roots
This study found that the biosynthetic pathways of coumestans in Eclipta prostrata are derived from acetate and shikimate pathways, while 3,5-di-O-caffeoylquinic acid biosynthesis originates exclusively from the shikimate pathway.
research Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing
This study found that electrospun membranes with aligned surface topography enhanced wound healing and hair follicle regeneration while modulating the immune response in a mouse skin wound model.
research The Rise in Adrenal Androgen Biosynthesis: Adrenarche
This review discusses the physiological process of adrenarche, its impact on behavior and skeletal maturation, and its variability across sex and race, but reports no new clinical results.
research Inhibition of 5α‐Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice
This study found that finasteride dose-dependently blocked the acquisition of ethanol drinking in mice and maintained reduced consumption even after treatment ended.
research Functional characterization of soybean strigolactone biosynthesis and signaling genes in Arabidopsis MAX mutants and GmMAX3 in soybean nodulation
This study found that strigolactone biosynthesis and signaling components in soybean may interact with other hormone pathways, influencing soybean development and nodulation.
research Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish
This study found that zebrafish with a mutation in the GDP-fucose biosynthesis gene exhibited enhanced and faster regeneration of mechanosensory hair cells, implicating the importance of this gene and Notch signalling regulation in hair cell regeneration mechanisms.
research Recent Advances in Multiple Strategies for the Biosynthesis of Sesquiterpenols
This study examined the latest advances in synthetic biology for increasing microbial production of sesquiterpenol compounds, highlighting innovative strategies to overcome challenges such as low yields and terpenoid-related toxicity, which hinder industrial-scale applications.
research Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate
In this study, the researchers found that depleting natural polyamines or manipulating translation rates can enhance the stemness of hair follicle stem cells, while N1-acetylspermidine increases proliferation without affecting translation.
research Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) in Arabidopsis thaliana
This review discusses the potential of using Arabidopsis thaliana to express fusion protein TDP1-KGF-2, aiming to enhance the transdermal delivery of KGF-2 for hair growth applications, despite current challenges with production costs and efficacy.
research Auxin Input Pathway Disruptions Are Mitigated by Changes in Auxin Biosynthetic Gene Expression in Arabidopsis
This study found that Arabidopsis mutants with disrupted auxin conversion pathways displayed low auxin phenotypes and increased biosynthetic gene expression, suggesting a feedback mechanism maintains auxin homeostasis.
research AabHLH112, a bHLH transcription factor, positively regulates sesquiterpenes biosynthesis in Artemisia annua
This study found that the AabHLH112 transcription factor positively regulates the biosynthesis of β-caryophyllene, epi-cedrol, and β-farnesene in Artemisia annua.
research Transcriptome sequencing and identification of cytochrome P450 monooxygenases involved in the biosynthesis of maslinic acid and corosolic acid in Avicennia marina
This study identified two cytochrome P450 enzymes in Avicennia marina leaves that may contribute to the biosynthesis of triterpenoids, potentially responsible for the plant's medicinal properties.
research A facile, biosynthetic design strategy for high-performance multifunctional bacterial cellulose-based dressing
In this study, a novel silver nanowires/collagen I/bacterial cellulose dressing demonstrated strong antibacterial activity and enhanced wound healing capabilities, while showing improved cytocompatibility and mechanical properties compared to traditional silver nanowire-based dressings.
research Transient treatment of pregnant Merino ewes with modulators of cortisol biosynthesis coinciding with primary wool follicle initiation alters lifetime wool growth
This study found that manipulating maternal cortisol levels during pregnancy altered Merino sheep wool characteristics, increasing fibre length and reducing crimp frequency in the offspring.
research Genome assembly of Stephania longa provides insight into cepharanthine biosynthesis
In this study, researchers used genomic, metabolomic, and transcriptomic methods to explore the biosynthetic capabilities of S. longa, aiming to better understand the species and lay the groundwork for future studies on the biosynthesis and therapeutic use of cepharanthine and similar alkaloids.
research Hepatoprotective and anti-hyperplastic effects of silver nanoparticles biosynthesised using aqueous extracts of M. scaber : Insights from acetaminophen and testosterone experimental models
This study found that silver nanoparticles synthesized using Mitracarpus scaber extract showed potential hepatoprotective and anti-hyperplastic effects in rats, suggesting novel therapeutic strategies for managing liver injury and benign prostatic hyperplasia.
research 865 Frontal fibrosing alopecia is associated with dysregulation of cholesterol biosynthesis pathways, fibrosis and mast cells
This study found that frontal fibrosing alopecia involves distinct molecular changes, such as downregulation of steroid and cholesterol pathways and upregulation of fibrotic and immune response genes, which may help guide treatment strategies.
research Hepatoprotective and anti-hyperplastic effects of silver nanoparticles biosynthesised using aqueous extracts of
In this study, researchers synthesized silver nanoparticles using an extract from Mitracarpus scaber and found them to have significant hepatoprotective and anti-hyperplastic effects in rats, suggesting potential for treating liver injury and benign prostatic hyperplasia.
research The Enzymic Derivation of Citrulline Residues from Arginine Residues In Situ during the Biosynthesis of Hair Proteins that are Cross-Linked by Isopeptide Bonds
Hair follicles have an enzyme that converts arginine to citrulline in proteins.
research Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer
In this study, Epimedii Folium extract was found to enhance melanin production and promote pigmentation through mechanisms involving the MAPK/ERK1/2 pathway in both in vitro and in vivo models.
research Sulfation of Minoxidil in Keratinocytes and Hair Follicles and the Stimulatory Effect of Minoxidil on the Biosynthesis of Glycosaminoglycans
Minoxidil boosts hair growth by undergoing a process in hair follicles and certain skin cells, and by increasing the production of compounds essential for hair growth and maintenance.
research 1331 Glutathione (GSH) distribution by quantitative MALDI imaging in reconstructed human skin upon activation of GSH biosynthesis by Nrf2 pathway activator
In laboratory models of human skin, this study found that treating with resveratrol significantly increased glutathione levels, potentially enhancing the skin's antioxidant defenses.
research A Review (Research and Patents) on Jasmonic Acid and Its Derivatives
This review discusses the synthesis and biological activities of jasmonates, highlighting their potential as drugs and prodrugs, but reports no new clinical results; further research and trials are anticipated.
research Oestrogen functions in skin and skin appendages
This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.
research Increased Polyamine Concentrations in the Hair of Cancer Patients
This article discusses the potential use of hair fibers to noninvasively measure polyamine concentrations as a marker of tumor growth, but reports no new clinical findings.
research THE ENTRY OF CA45 INTO THE SKIN AND OTHER SOFT TISSUES OF THE RAT: AN AUTORADIOGRAPHIC AND SPODOGRAPHIC STUDY
This study demonstrated radiocalcium uptake in skin, eye, cartilage, and mucous glands, with the highest concentration in the hair follicle's keratogenous zone.