December 2021 in “Egyptian Journal of Dermatology and Venereology” This study found that patients with female pattern hair loss had higher oxidative stress levels and lower antioxidant enzyme activities than healthy controls, suggesting oxidative stress may play a key role in disease progression.
May 2023 in “Journal of Cosmetic Dermatology” This study found that AGA patients had higher serum and epidermal irisin levels, which were associated with metabolic syndrome, dyslipidemia, and abnormal carotid intima media thickness, suggesting potential irisin resistance affecting cardiometabolic health.
122 citations
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October 2013 in “PEDIATRICS” This study observed that cortisol concentrations in hair, indicating prolonged stress, are correlated between mothers and young children, suggesting potential heritable traits or maternal influence.
73 citations
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October 2003 in “Journal of Pharmacology and Experimental Therapeutics” This study found that hair depigmentation in mice and humans can be a dynamic indicator of KIT inhibition by the drug SU11248, correlating with treatment periods.
55 citations
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October 2015 in “Journal of Investigative Dermatology” Alopecia areata is linked to immune-related genes, suggesting JAK inhibitors as a potential treatment.
50 citations
,
July 2018 in “Psychoneuroendocrinology” In this study, researchers found that tritiated cortisol was incorporated into the hair of rhesus monkeys primarily as cortisol and cortisone, as well as other metabolites, after systemic administration.
23 citations
,
January 2016 in “Brazilian Journal of Psychiatry” This study observed that drug-naïve first-episode psychosis patients had higher hair cortisol concentrations than healthy controls, and these concentrations correlated with the severity of psychopathology.
22 citations
,
May 2019 in “Animals” In this study, researchers found that high hair cortisol levels, indicating stress in cows, were associated with certain shelter and cow-level conditions such as unclean environments and physical injuries.
21 citations
,
January 2016 in “NeuroImmunoModulation” This study found that daily hair washing was associated with significantly lower hair cortisol concentrations, suggesting it may influence the accuracy of using hair cortisol as a biomarker for chronic stress.
20 citations
,
April 2014 in “Dermatologic Therapy” This study reported that sulfotransferase activity in plucked hair follicles can predict treatment response to 5% topical minoxidil in women with androgenetic alopecia with high sensitivity and specificity.
15 citations
,
March 2021 in “EMBO Reports” PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.
14 citations
,
September 2017 in “Proteomics. Clinical applications” This review discusses advancements and gaps in using proteomics for hair testing and its potential in developing a medical proteome repository, but reports no new research findings.
11 citations
,
April 2013 in “Journal of Proteomics” This study identified proteins that are differentially expressed in balding versus non-balding dermal papilla cells, potentially aiding the understanding and treatment of androgenetic alopecia.
8 citations
,
September 2018 in “Journal of Cosmetic Dermatology” This study found that serum irisin levels were significantly lower in patients with acne vulgaris compared to healthy controls and were negatively correlated with insulin resistance and disease severity.
4 citations
,
September 2019 in “Journal of Biomedical Optics” This study found that near-infrared microscopy can effectively detect complete medulla loss in scalp hair, which may serve as a potential biomarker for breast cancer diagnosis.
3 citations
,
October 2021 in “The Application of Clinical Genetics” This study found that certain genetic variations in the OPN gene may be linked to atopic dermatitis and a higher prevalence of asthma in Caucasians.
2 citations
,
December 2022 in “The Journal of Dermatology” This study found that patients with hidradenitis suppurativa had significantly higher levels of cell-free DNA in their serum compared to healthy controls, suggesting its potential as a biomarker for the disease.
2 citations
,
May 2022 in “Diagnostics” This study confirmed that 25(OH)D3 can be detected in hair samples from healthy young adults, but no correlation was found between hair and serum 25(OH)D3 concentrations, indicating limited potential as a standalone biomarker.
2 citations
,
January 2020 in “Benha Journal of Applied Sciences” This study found that serum 8-Hydroxydeoxyguanosine levels were significantly higher in alopecia areata patients compared to healthy controls, suggesting its potential as a diagnostic and prognostic biomarker for the condition.
1 citations
,
November 2023 in “Dermatological Reviews” This review highlights advancements in skincare aimed at addressing the effects of aging and environmental factors, including new techniques to rejuvenate skin cells and reduce inflammation, though challenges like complex routines and costs limit widespread adoption.
1 citations
,
October 2020 in “Journal of Cosmetic Dermatology” This study found that metabolic syndrome was more prevalent among androgenetic alopecia patients than controls, with higher serum RANTES levels suggesting a potential role in the syndrome's pathogenesis.
1 citations
,
September 2016 in “Brain Behavior and Immunity” Hair cortisol levels can indicate stress and are affected by washing frequency, not cosmetic treatments.
June 2026 in “Frontiers in Oncology” In this study, researchers found that deficiencies in Gsdma1/2/3 significantly inhibited the initiation and progression of cutaneous squamous cell carcinoma (cSCC) in mice, suggesting GSDMA's role in promoting cSCC proliferation and its potential as a therapeutic target.
This study found that in the Jordanian population, elevated cortisol levels were significantly associated with progressive keratoconus, whereas lower cortisol levels were linked to stable disease, suggesting cortisol may be a potential biomarker for monitoring keratoconus progression.
February 2026 in “Expert Review of Endocrinology & Metabolism” This review discusses the dermatologic manifestations and management of polycystic ovary syndrome, underscoring the need for mechanism-based, personalized treatments and integrated mental health support, but reports no new clinical results.
October 2025 in “European Journal of Translational and Clinical Medicine” This study found that women with polycystic ovary syndrome had significantly higher serum dihydrotestosterone levels than healthy controls, supporting its use as a reliable biomarker for early detection of the condition.
July 2025 in “The Egyptian Journal of Hospital Medicine” This study found that serum GPER-1 levels may serve as a biomarker for differentiating androgenetic alopecia from telogen effluvium and healthy controls, although its ability to distinguish between AGA and TE is limited.
May 2025 in “OSF Preprints (OSF Preprints)” Machine learning can help identify stress indicators in mothers and infants.
January 2025 in “International Journal of Forest Animal and Fisheries Research” This review found that while elevated DHEA levels are observed in some women with PCOS, especially those with hyperandrogenism, inconsistencies across studies suggest that standardized measurement and analyses are needed to clarify DHEA's role as a biomarker and factor in PCOS pathophysiology.
October 2024 in “Skin Appendage Disorders” This study found that serum FABP4 levels were significantly higher in alopecia areata patients compared to healthy controls and may correlate with disease severity.