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This review outlines recent advancements in biomimetic materials for skin regeneration, emphasizing their potential to mimic tissue structures and regulate physiological processes, and discusses future directions involving novel technologies like artificial intelligence and in situ reprogramming.

This review reports that 3D skin bioprinting has made significant progress towards clinical application, particularly in wound healing and disease modeling, but further work on vascularization and bioink standardization remains crucial.

This review highlights that biomaterial properties can be designed to modulate macrophage activity, potentially reducing foreign body responses and enhancing tissue healing in regenerative medicine.

This review suggests that self-organizing tissues like organoids could revolutionize material production by enabling sustainable and complex biological systems, such as spider silk glands, to surpass current synthetic designs, though challenges in model species expansion and production scaling remain.

This review examines glycopeptide hydrogels as biomimetic materials for tissue regeneration and other biomedical applications, describing their design, properties, and potential uses, and highlighting future advancements in replicating natural tissue environments for precision medicine.

This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.

This study reported that 4D-printed, aliphatic polycarbonate-based scaffolds supported adipose tissue engineering by allowing adipocyte infiltration and neovascularization in vivo, indicating potential for effective adipose tissue repair.

In this review, the authors examined the role of the extracellular matrix in cancer progression and highlighted how decellularization techniques are used to create biomimetic tumor models, discussing the potential for personalized and predictive cancer treatments using advanced biomaterials combined with AI and machine learning.

This review discusses how combining single-cell RNA sequencing and 3D bioprinting is advancing skin tissue engineering by enhancing cellular-level precision and addressing challenges like vascularization, ultimately improving regenerative outcomes and therapeutic strategies.

This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.

This study demonstrated that a bio-3D printed artificial skin scaffold, seeded with adipose-derived mesenchymal stem cells, showed promising wound healing properties by enhancing cell recruitment, migration, and gene expression related to tissue regeneration.

This article reviews the potential of using PBM in 3D tissue engineering to improve cell viability under stress conditions but reports no new experimental findings.

This study demonstrated that intraoperative bioprinting using a bioink with human adipose-derived extracellular matrix and stem cells achieved successful reconstruction of full-thickness craniomaxillofacial skin defects in rats, promoting wound closure, adipogenesis, and hair follicle-like structure formation within two weeks.

In this study, researchers demonstrated that fibroblasts derived from human embryonic stem cells can be used to create tissue-engineered dermal substitutes, effectively repairing mouse skin wounds within 20 days, highlighting a promising method for clinical applications in skin repair.

In this study, researchers found that hydrogel scaffolds loaded with Runx2-overexpressing BMSCs significantly enhanced bone regeneration and osteogenic differentiation, offering new insights into treating large bone defects.

This study demonstrates that 3D bioprinting is advancing toward practical use in reconstructive medicine, with promising results in personalized skin grafts, hair regeneration, and burn care, despite existing technical and ethical challenges.

This dissertation investigated barriers to clinical translation of adipose-derived mesenchymal stem cell-based vascular grafts, highlighting issues with thrombosis in diabetic patients and proposing alternative cell sources to improve applicability.

This study developed keratin-based hydrogels with improved water solubility and tunable properties, demonstrating excellent cytocompatibility, suggesting potential for biomedical applications.

This review highlights that incorporating nanomaterials into scaffolds can significantly enhance angiogenesis in tissue regeneration by simulating extracellular matrix structures and effectively delivering angiogenesis-related factors, offering promising designs for vascularization and therapeutic applications.

This review highlights advancements in skin tissue engineering in China over the past 20 years and reports no new clinical findings, noting future potential for artificial skin in burn treatment.

This review explores the potential of nanozymes as artificial enzymes with diverse applications but highlights the need for more research into their mechanisms, safety, and scalability before they can be effectively translated into clinical use.

This study examined 3D-printed scaffolds coated with polydopamine and observed that they significantly enhanced osteogenesis and angiogenesis in vitro and in a rat cranium defect model, suggesting their potential for repairing large bone defects.

Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.

This study presents a novel, scalable method for preparing highly hair-inductive tissue grafts using a bioprinter, which enhances hair follicle regeneration in mice, although most hair shafts remained beneath the skin.

Bioactive peptides improve graft survival and new hair growth.

This review discusses how engineering cell surfaces with polyelectrolytes can address challenges in cell therapy and related biomedical fields and reports no new research findings.

This study suggests that 3D bioprinting may become a practical solution for tissue regeneration and complex wound care, demonstrating improved outcomes over traditional methods in various applications.

This study highlights the successful design of recombinant fortilin constructs for potential drug development targeting atherosclerotic plaque formation in cardiovascular disease.

This review summarizes recent advancements in three-dimensional bioprinting technology and hydrogel bioinks, highlighting their applications in tissue engineering, but reports no new experimental results.