Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, applying a biodegradable microneedle patch after topical steroid application significantly increased steroid penetration and improved treatment outcomes in patients with prurigo nodularis compared to the control.

This study suggests that newly developed micro-pigment-encapsulated biodegradable microneedles accurately implant pigments in pig cadaver skin, potentially advancing scalp micro-pigmentation methods.

This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.

This review discusses the design strategies and applications of long-acting polymeric microneedles, noting their potential to improve patient compliance and reduce side effects in chronic disease management, but reports no new experimental results.

In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

In this study, researchers developed a biodegradable microneedle made of hyaluronic acid, intended to enhance drug delivery through the skin's stratum corneum and potentially promote hair growth by overcoming the skin's barrier function in alopecia treatment.

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

In this study, a patch with microneedles regrew hair in shaved mice within six days, suggesting potential for treating hair loss in humans.

This review explores the potential, challenges, and recent advancements of dissolving microneedles in drug delivery, summarizing their varied applications and current limitations without providing new clinical results.

The microneedle arrays effectively promote wound healing and have potential for clinical use.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This review discusses the integration of nanoparticles with microneedles to improve drug delivery through enhanced stability, bioavailability, and controlled release, noting ongoing challenges with stability, scalability, and safety.

This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.

This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.

This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.

This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.

Smart microneedles using advanced tech could improve psoriasis treatment.

This review presents recent advancements in bio-degradable polymers made through green chemistry, highlighting eco-friendly raw materials and methods, while also identifying challenges and future research areas to enhance their sustainability and commercial viability.

This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.

This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

This review examines microneedle patches for drug delivery, detailing their designs, materials, manufacturing methods, and potential advantages, but reports no new clinical results.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.

This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.

This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.

This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.

This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.