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The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.

Advancements in hair biology include new treatments and tools for hair growth and alopecia.

Hair and nails are skin parts that develop early and serve protective and functional roles.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Finasteride effectively treats BPH, but needs more trials to understand potential.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Fungi-produced compounds can change plant root growth.

Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.

High androgen levels in young women with PCOS are linked to higher blood pressure.

AXR3 and SHY2 genes control the growth and timing of root hair development in plants.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Oxidative stress contributes to hair graying and loss as we age.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.