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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

Lifestyle changes and weight loss are key for treating PCOS-related metabolic issues and infertility, with various medications available for specific symptoms.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

New treatments for immune disorders caused by FOXN1 deficiency are promising.

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

Vesicular carriers like liposomes may improve cosmetic skin treatment delivery and effectiveness but need more human research.

Delayed ejaculation is a complex issue caused by psychological, biological, and lifestyle factors, requiring a holistic treatment approach.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

The document reports the first Brazilian case of a girl with Becker nevus syndrome, characterized by skin changes, breast underdevelopment, and scoliosis.

Some medications for bladder problems can cause memory issues or mood changes, and doctors should monitor these side effects.

Selenium-enriched green tea might be a safe prebiotic for gut health.

A rare genetic mutation found in an Indian family can be detected through prenatal screening.

Valproate is a mood stabilizer for bipolar disorder but has side effects and risks, especially during pregnancy.

Hair changes can indicate systemic diseases or medication effects.

Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

A girl with Becker's nevus syndrome showed good improvement in breast development using spironolactone.

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

Some epilepsy drugs can cause reproductive and cosmetic side effects in women and affect pregnancy, but most women still have healthy babies.

Recognizing congenital triangular alopecia is crucial to avoid unnecessary treatments.

Stress, nutritional issues, and chronic diseases can cause hair loss, and nail changes may signal internal diseases; treatment focuses on the underlying cause.

A boy with severe immune deficiency and Epstein-Barr virus died from high-grade B-cell lymphoma.

Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.

Different hair and scalp disorders cause hair loss or excess hair growth, with various treatments available depending on the specific condition.

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

The document explains hair and nail biology, common hair loss conditions and treatments, oral and genital skin diseases, and the risks and treatments associated with squamous cell carcinoma.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.