research Mouse Models for the Study of Human Hair Loss
Mice are useful for researching human hair loss and testing treatments, despite some differences between species.
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research Use of Androgen Lowering Medications Finasteride and Dutasteride Do Not Substantially Alter Risk of Incident HCV-Related Hepatocellular Carcinoma in Men
Androgen lowering medications don't significantly change HCV-related liver cancer risk in men.
research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow
Topical drugs and near-infrared light therapy show potential for treating alopecia.
research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands
Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.
research Significance of the Polyglutamine Tract Polymorphism in the Androgen Receptor
The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.
research New Insight of PSA Reduction During Finasteride Therapy
Finasteride reduces PSA levels by around 40-50% in BPH patients.
research Is the Sulfonamide Group of Tamsulosin the Main Factor in the Pathophysiology of Floppy Iris Syndrome?
Tamsulosin's sulfonamide group may contribute to floppy iris syndrome.
research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid, and Carnitine-Containing Compound in Prostate and Hair Follicle Cell-Based Assays
The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.
research Clinics in Diagnostic Imaging: A 55-Year-Old Man with Benign Prostatic Hyperplasia and Extraperitoneal Bladder Perforation
A bladder rupture from prostate treatment was healed with catheterization and antibiotics.
research Reply to Finasteride and Dutasteride May Reduce Melanoma Risk
Finasteride and dutasteride may lower melanoma risk, with teenage acne possibly indicating higher risk.
research Therapeutic Hotline: Treatment of Androgenic Alopecia with Finasteride May Result in High-Grade Prostate Cancer in Patients: Fact or Fiction?
Finasteride for hair loss is safe and does not increase the risk of high-grade prostate cancer.
research Circulating and Intraprostatic Sex Steroid Hormonal Profiles in Relation to Male Pattern Baldness and Chest Hair Density Among Men Diagnosed with Localized Prostate Cancers
Baldness in men with prostate cancer is linked to higher levels of certain sex hormones, but chest hair density is not.
research Two Cases of Low Prostate-Specific Antigen Localized Prostate Cancer Incidentally Detected by Computed Tomography
CT scans can find serious prostate cancer even when PSA levels are low.
research Assessing Finasteride-Associated Sexual Dysfunction Using the FAERS Database
Finasteride use linked to increased risk of sexual dysfunction, especially in younger people.
research Should Finasteride Be Routinely Given Preoperatively for TURP?
Finasteride may reduce bleeding after TURP, but more research needed.
research Redefining Hormone Resistance in Prostate Cancer
The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.
research Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents
Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.
research Five-Alpha-Reductase Inhibitors for Prostate Cancer Prevention
5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.
research Pharmacology of Antiandrogens
Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.
research Finasteride And Dutasteride May Reduce Melanoma Risk
Finasteride and dutasteride might lower melanoma risk.
research Annotated Patent Selections
The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.
research Is Male Androgenetic Alopecia A Sign Of The Male Equivalent Of Polycystic Ovary Syndrome Or Metabolic Syndrome?
Men with early hair loss and hormonal changes like PCOS could be the male equivalent of PCOS, not linked to metabolic syndrome.
research Preparation of Novel Polymeric Microspheres for Controlled Release of Finasteride
PPCM microspheres allow controlled finasteride release over 24 hours.
research Inhibition of the Androgen Receptor by Antisense Oligonucleotides Regulates the Biological Activity of Androgens in SZ95 Sebocytes
Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.
research Melatonin Receptors and Their Role in Human Diseases
Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.
research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors
Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.
research Male-Pattern Baldness, Common Latent Viruses, and Microcompetition
Common latent viruses might contribute to male-pattern baldness by disrupting cell processes that normally suppress hair loss-related proteins.
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production
Testosterone's muscle-building effects do not require its conversion to DHT.
research Identification of 5α-Reductase Isoenzymes in Canine Skin
Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.
research Association of Androgenetic Alopecia with a More Severe Form of COVID-19 Infection
Men with androgenetic alopecia and hypertension may experience more severe COVID-19.