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This study found that chronic treatment with EE/LNG in female rats decreased brain concentrations of allopregnanolone, leading to reduced social and sexual behaviors; progesterone administration reversed these effects, except when finasteride was used to block the increase.

This study found that progesterone and its metabolite, allopregnanolone, provided anti-anxiety and anti-depressive effects in female mice, potentially independent of nuclear progestin receptors but requiring 5α-reduction and estradiol's influence on brain-derived neurotrophic factor.

This study observed that gender-affirming hormone therapy differentially affects metabolism in mice, with the specific metabolic impacts dependent on the type of hormonal treatment used.

This study found that suppressing allopregnanolone production in late gestation fetal sheep altered CNS activity and behavioral responses to transient asphyxia, effects mitigated by an analog co-infusion.

This study found that pre-treatment with the neurosteroid allopregnanolone in mice reduced nicotine withdrawal symptoms, suggesting potential therapeutic benefits for nicotine dependence.

In this study, supplementing adult Bichon Frises with 600 mg/kg Omega-3 PUFAs significantly improved their skin health, hair quality, feeding behavior, and metabolic health, compared to a control diet, over six weeks.

This study found that finasteride treatment in male rats has lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation, and gut microbiota composition even one month after discontinuation.

This study found that vertical sleeve gastrectomy improved metabolic, behavioral, and reproductive symptoms in a rat model of PCOS, suggesting it may be a potential therapy for specific aspects of PCOS.

This review discusses the off-label use of SSRIs to manage inappropriate sexual behavior in elderly dementia patients and highlights the unclear risk of post-SSRI sexual dysfunction, noting a need for high-quality clinical trials.

This study found that Muse cells, when injected subcutaneously, alleviated symptoms of atopic dermatitis in mice, suggesting potential for treating inflammatory skin conditions.

This study found that frequent consumption of sweetened tea drinks is linked to an increased risk of female androgenetic alopecia, with the risk further heightened by late bedtimes, but sleep behavior rather than sugar intake mediates the association.

Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.

This study found that hidradenitis suppurativa significantly impacts patients' sexuality, with many experiencing fear of rejection, perceived unattractiveness, and negative effects on relationships and sexual activity.

Sleep may mediate the link between sugary drinks and female hair loss.

This study observed that overexpressing TSPO in the hippocampal dentate gyrus of mice led to significant anxiolytic and antidepressant-like effects, potentially mediated by increased allopregnanolone synthesis.

This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.

In this study, researchers found that long-term treatment with 5-alpha-reductase inhibitors improved depression-like symptoms more effectively than a short-term treatment followed by withdrawal in d-galactose-induced senescent male rats, by reducing brain inflammation and oxidative stress.

In this study, chronic exposure to finasteride induced metabolic disturbances and depression-like behaviors in young male rats, similar to those caused by obesity, but did not worsen anxiety or depression in obese rats.

In this study, higher concentrations of environmental metals, particularly manganese, were linked to worse self-reported attention-related behaviors in adolescents from Italy, with no significant modification of this effect by iron status.

This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.

In this study, researchers developed a carboxylated β-cyclodextrin formulation to enhance finasteride's physicochemical properties, achieving an encapsulation efficiency of about 85% and indicating potential for controlled drug release in therapeutic applications. Their findings suggest this inclusion complex could improve delivery of hydrophobic drugs like finasteride.

This review discusses advancements in skin microphysiological systems, such as 3D bioprinting, skin organoids, and skin-on-a-chip, and their effectiveness in emulating human skin functions for research and preclinical applications, highlighting the potential for replacing animal testing with these innovative technologies.

Homemade hair treatments can significantly lower drug levels in hair, possibly causing false-negative drug tests.

In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.

Different oils affect hair flexibility and strength, with their impact varying on whether hair is virgin or bleached.

This case study reports successful treatment of an 11-year-old girl's trichotillomania with cognitive behavioral therapy, mild topical treatments, and supportive parental involvement, without psychopharmacologic intervention.

This study found that in domestic cats, black hair contained significantly higher cortisol concentrations than white hair, whereas ginger hair showed no significant difference compared to white hair. Additionally, a positive correlation was reported between hair cortisol levels and behavioral issues mentioned by cat owners.

This case report describes a rare instance of a patient with trichotillomania also developing a gastric trichobezoar, leading to Rapunzel syndrome.

This review discusses trichotillomania, including its diagnosis and management, and emphasizes the importance of a psychiatry-dermatology liaison alongside behavioral therapy and pharmacological options.