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Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Children, especially teenagers, can get severe SARS-CoV infection with symptoms similar to adults, but they typically recover well with supportive care.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Eating fewer calories, less sugar and refined carbs, and more low-glycemic and omega-3 rich foods can help manage PCOS symptoms.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Skin has specialized touch receptors that can tell different sensations apart.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Certain mice without specific receptors or mast cells don't lose hair from stress.

Targeting the skin's endocannabinoid system could help treat skin disorders.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Prolactin affects when mice shed and grow hair.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Neurosteroids show promise for treating epilepsy and more research is needed.