October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.
April 2021 in “Arab Journal of Nuclear Sciences and Applications/Arab Journal of Nuclear Sciences and Applications ” This study found that repeated use of a protein hair conditioner, followed by hot air and gamma irradiation, may lower serum collagen I and increase heat shock protein concentrations in rats, suggesting potential cumulative risks.
25 citations
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November 2021 in “Toxins” This review discusses the use of bee venom in skin cosmetics and highlights safety concerns related to potential immune reactions, but it reports no new clinical results.
2 citations
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September 2023 in “Foods” In this study, researchers developed microcapsules and effervescent tablets containing policosanol from insect wax, achieving high encapsulation efficiency and rapid water dispersion, effectively addressing the challenges of solubility and psychological acceptance in consuming insect-based lipids.
April 2006 in “Dermatologic Clinics” This study found that white wax and its extract significantly promoted hair growth in a mouse model of androgenetic alopecia, outperforming finasteride by inhibiting 5α-reductase activity and enhancing cellular proliferation.
August 2005 in “Microscopy and Microanalysis” Polymethylene wax in hair relaxers makes hair smooth and shiny with less damage.
Bee pollen, green tea, essential oils, and various plant extracts improve skin and hair health.
August 2025 in “Journal of Pure and Applied Microbiology” This review discusses various therapeutic properties of bee venom, including its potential against cancer, infections, and inflammatory diseases, but notes limitations in clinical application due to variability and safety concerns, calling for further research.
This paper presents a clinical case showing the potential effectiveness of bee venom for treating cutaneous varicosities and reviews its dermatological applications, though research is limited.
2 citations
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October 2022 in “Jikken Dobutsu” This study found that Philippines stingless bee propolis extract promotes hair growth in mice by activating the Wnt/β-catenin signaling pathway and stimulating hair follicle development.
39 citations
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June 2019 in “Toxins” This review explores the therapeutic potential of bee venom for treating various skin diseases, discussing its mechanisms and effects but reports no new clinical findings.
June 2026 in “International Journal of Innovative Science and Research Technology (IJISRT)” This study evaluated a natural, herbal-based powder formulation aimed at removing unwanted facial hair while promoting skin health, finding that the product was effective and well-suited for use based on physical properties and user feedback.
27 citations
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February 2017 in “Biomedicine & Pharmacotherapy” This study found that white wax and its extract may promote hair growth in a mouse model of androgenetic alopecia by inhibiting 5α-reductase activity and increasing cell proliferation, with efficacy surpassing finasteride.
January 2022 in “Pharmaceutical Sciences Asia” This study found that a liposome containing butterfly pea flower extract and clove oil was stable and, when used by 15 volunteers over 60 days, enhanced eyebrow thickness and darkness without causing irritation.
1 citations
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March 2025 in “Journal of Society of Cosmetic Chemists of Japan” In this study, BECD-treated wavy hair showed reduced undulation and improved straightening after drying, as BECD enhanced the contraction and rearrangement of molecular chains in non-keratin proteins, unlike untreated hair, which retained its wavy structure.
11 citations
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August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.
35 citations
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April 2024 in “Life” This literature review explored the potential therapeutic applications of bee venom, Ficus carica, and Geranium essential oil in treating skin conditions like vitiligo, melasma, and melanoma, concluding these natural products may offer anti-inflammatory, antibacterial, and antioxidant benefits for dermatological care, especially for diabetic patients.
August 2021 in “Research Square (Research Square)” This study found that BEO inhibited cell proliferation and inflammatory mediator release in a human keratinocyte acne model and reduced acne lesion severity in a rabbit model, suggesting its potential as a natural alternative to conventional acne treatments.
2 citations
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February 2024 in “Toxins” This study found that bee venom accelerated the transition from the telogen to anagen phase in mice, increasing hair growth by day 14, and suggested that bee venom may enhance adipose-derived stem cell activity by upregulating growth factor secretion.
March 2026 in “BMC Veterinary Research” This case report describes the successful use of bovine amniotic membrane preserved in propolis for promoting rapid wound healing and hair regrowth in a cat with extensive skin necrosis.
November 2025 in “EXPERIMENTAL ANIMALS” In this murine study, researchers found that topical treatment with Philippine stingless bee propolis increased folliculogenesis, epidermal thickness, and melanogenesis, but not hair length, potentially supporting hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia models.
12 citations
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January 2019 in “AIP conference proceedings” This study observed that rough propolis from Indonesian bees showed significant cytotoxic effects against cancer cell lines, with higher inhibition percentages than smooth propolis, suggesting its potential as an anticancer agent.
1 citations
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September 2022 This study found that sugar waxing led to slower hair growth and reduced hair thickness, but increased ingrown hair and inflammation compared to hard waxing.
25 citations
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May 2020 in “Progress in Organic Coatings” This study found that bio-based waterborne polyurethanes derived from castor oil may offer effective hair-styling performance without skin irritation and appear to be safer for the environment compared to traditional hair sprays.
7 citations
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April 2009 in “Bioorganic & Medicinal Chemistry Letters” Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
76 citations
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February 2015 in “Industrial Crops and Products” This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
This study provides genomic and epigenomic insights into the white wax scale insect, highlighting high methylation levels and differential hormone profiles linked to its sexual dimorphism and developmental differences.
In this study, researchers developed vegan exosome-like vesicles from microalgae that mimic mammalian exosomes, demonstrating promising in vitro, ex vivo, and clinical effects such as improved wrinkle depth and elasticity, making them a potential alternative in cosmetic applications.
January 2016 in “Frontiers in Bioengineering and Biotechnology” This study observed that in a mouse wound model, honey significantly accelerated wound healing when compared to povidone-iodine treatment, suggesting its potential regenerative benefits.
2 citations
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June 2016 in “Journal of Medical Science And clinical Research” This study examines the potential effectiveness of Barever natural hair inhibitor, which includes papaya and other herbal ingredients, in reducing hair growth permanently when applied after hair removal.