June 2022 in “Biotechnological Research” This review discusses the potential of activated autologous platelet-rich plasma (aaPRP) for improving diabetic foot ulcer outcomes but reports no new clinical results, noting the need for further evidence.
April 2021 in “Journal of Investigative Dermatology” This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.
January 2014 in “Indian dermatology online journal” This article reviews various treatments for leg ulcers, emphasizing therapies like compression, NPWT, HBOT, and potential future avenues like stem cells, but it does not report new research results.
8 citations
,
January 2018 in “Middle East Journal of Digestive Diseases” This case report describes a middle-aged man with alopecia universalis and ulcerative colitis, where hair regrowth occurred following treatment with azathioprine and mesalamine.
33 citations
,
February 2024 in “International Journal of Molecular Sciences” This study highlights the crucial, multifaceted roles of fibroblasts in wound healing and various diseases, including their dysregulation in diabetic foot ulcers, underscoring the need for targeted therapies to address complications and morbidity from such chronic conditions.
25 citations
,
January 2018 in “Acta Clinica Croatica” This study found that allogeneic platelet gel significantly improved healing in non-healing chronic lower leg ulcers compared to hydrogel treatment.
August 2025 in “Scientific Reports” This study found that hair follicle transplantation improved wound healing in diabetic mice by promoting tissue regeneration and reducing inflammation, with follicles from normoglycemic conditions proving more effective than those from hyperglycemic environments.
31 citations
,
November 2000 in “Journal of the European Academy of Dermatology and Venereology” This article discusses the diverse dermatological symptoms associated with sexual abuse, highlighting the challenges in establishing causal links and the potential long-term psychosomatic manifestations, without reporting new research results.
63 citations
,
October 2012 in “Wound Repair and Regeneration” This study found that transplanting autologous scalp follicular grafts into chronic leg ulcers led to a greater reduction in ulcer size compared to non-grafted areas, suggesting a promising therapeutic alternative.
11 citations
,
January 2019 in “Dermatologic Surgery” In this study, hair follicle transplantation into nonhealing ulcers promoted rapid wound closure, with differing scar quality and hair growth between the central and peripheral wound areas.
May 2021 in “Clinical Endoscopy” This study found that adding platelet-rich plasma to standard treatment reduced rebleeding in patients with peptic ulcer bleeding compared to additional epinephrine injections.
12 citations
,
June 2023 in “International Journal of Molecular Sciences” This review examines the potential of biomaterial-based wound dressings in managing diabetic foot ulcers, highlighting their versatility and therapeutic properties for promoting wound healing in individuals with diabetes mellitus.
3 citations
,
January 2020 in “Journal of Cutaneous and Aesthetic Surgery” This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.
September 2025 in “Frontiers in Pharmacology” This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.
14 citations
,
February 2023 in “Frontiers in Bioengineering and Biotechnology” This review details various components used in hydrogel composites for treating chronic diabetic ulcers and highlights potential future materials but reports no new empirical findings.
112 citations
,
October 2008 in “Wound Repair and Regeneration” This study demonstrated that disrupting sonic hedgehog signaling, using cyclopamine, significantly impaired wound healing in a mouse model, suggesting its crucial role in postnatal tissue repair.
7 citations
,
February 2022 in “Stem cell reviews and reports” This review discusses the heterogeneity and plasticity of epithelial stem cells in skin homeostasis, wound healing, and tumorigenesis, reporting no new results but emphasizing the need for further exploration of key regulatory mechanisms.
1 citations
,
February 2025 in “Cell Cycle” This study found that implanting hair-follicle-associated pluripotent stem cell sheets in mice significantly accelerated wound closure and reduced scar formation compared to non-implanted controls.
17 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that Stat3 removal in keratinocytes of mice impairs healing and disrupts the normal hair cycle, leading to skin ulcers and hair loss as they age.
11 citations
,
February 2018 in “Medical science monitor” This study found that an alternating inflatable head pad significantly reduced the incidence and severity of occipital pressure ulcers and alopecia in patients undergoing open heart surgery, suggesting improved postoperative nursing and patient quality of life.
2 citations
,
September 2023 in “Journal of clinical medicine” This study found that using autologous ultra-thin split-thickness skin grafts from the scalp with the DermaBlade tool led to rapid wound healing, minimal complications, and improved cosmetic outcomes for 90% of patients with lower extremity lesions, without causing scarring or alopecia.
2 citations
,
May 2023 in “Frontiers in Bioengineering and Biotechnology” This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.
2 citations
,
September 2022 in “Cytotherapy” This review summarizes recent research on the therapeutic uses of adipose-derived stem cells for wound healing and treating skin diseases but does not provide new experimental results.
February 2025 in “Journal of Tissue Viability” This scoping review suggests that physiological differences in skin structure may affect how individuals with different skin tones respond to pressure ulcer development, emphasizing the need for targeted prevention strategies.
July 2023 in “Stem Cells Translational Medicine” This review discusses the roles of mesenchymal stem cells in wound healing, particularly their interactions with immune cells, and highlights the potential and current limitations of MSC-based therapies for tissue regeneration.
January 2021 in “Springer eBooks” This chapter reviews skin manifestations in common rheumatic diseases, particularly those with polyarthritis, and offers a differential diagnosis of erythema nodosum without presenting new research findings.
2 citations
,
January 2016 in “Sarcoma” This study found that using a recombinant adenoassociated virus to induce survivin expression protected normal tissues from radiation damage in mice, reducing side effects compared to controls.
34 citations
,
January 2022 in “Frontiers in Immunology” This study found that IL-25-mediated-IL-17RB signaling improved diabetic wound healing by enhancing angiogenesis, collagen deposition, and endothelial cell function, suggesting a potential therapeutic strategy for poorly healing diabetic wounds.
7 citations
,
December 2024 in “Antibiotics” This review discusses the potential of cathelicidins in treating skin conditions but highlights significant challenges, including unclear clinical efficacy, safety concerns, and bacterial resistance, that must be addressed for successful medical application.
1 citations
,
September 2024 in “Journal of Investigative Dermatology” Ancestry affects skin healing, with non-Hispanic Black patients showing more healing-related fibroblasts than White patients.