48 citations,
March 2010 in “PloS one” C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.
25 citations,
December 2007 in “Developmental biology” Clim proteins are essential for maintaining healthy corneas and hair follicles.
16 citations,
April 2021 in “Frontiers in Cell and Developmental Biology” New hair follicles could be created to treat hair loss.
January 2024 in “Biomaterials Research” 3D-cultured cells in HGC-coated environments improve hair growth and skin integration.
2 citations,
August 2019 in “Journal of skin and stem cell” The study concludes that regulating apoptosis could lead to new treatments for various skin and hair conditions.
1 citations,
July 2023 in “Communications biology” Removing Mediator 1 from certain mouse cells causes teeth to grow hair instead of enamel.
35 citations,
June 2012 in “PloS one” Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
9 citations,
September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
7 citations,
July 2013 in “InTech eBooks” Oral lichen planus is a chronic disease causing mouth discomfort and sometimes needs immunosuppressive treatment.
39 citations,
November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Fatp4 is crucial for healthy skin development and function.
April 2023 in “Dentistry” Baby teeth stem cells can potentially grow organs and treat diseases.
105 citations,
October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
August 2023 in “International Journal of Molecular Sciences” Human skin xenografting could improve our understanding of skin development, renewal, and healing.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
13 citations,
July 2012 in “Pigment Cell & Melanoma Research” A mutation in the Adam10 gene causes freckle-like spots on Hairless mice.
168 citations,
August 2009 in “EMBO molecular medicine” Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
1 citations,
April 2018 in “Journal of Investigative Dermatology” Oleoylethanolamide (OEA) safely boosts fat production in skin cells and may help treat dry skin and reduce inflammation.
73 citations,
April 2013 in “Stem cells” LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.
33 citations,
June 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
September 2023 in “Stem cell reviews and reports” Scientists found a new, less invasive way to get stem cells from horse hair for veterinary medicine.
Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.
Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.
1 citations,
January 2018 in “Elsevier eBooks” The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.
87 citations,
March 2014 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids” Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.
29 citations,
December 2005 in “BioEssays” Wnt/ß-catenin signaling is crucial for regulating skin stem cells and hair growth, with the right levels and timing needed for proper function.
165 citations,
September 2001 in “Genes & development” CDP is crucial for lung and hair follicle cell development.
6 citations,
January 2009 in “Elsevier eBooks” The skin has multiple layers and cells, serves as a protective barrier, helps regulate temperature, enables sensation, affects appearance, and is involved in vitamin D synthesis.
143 citations,
September 2008 in “Experimental gerontology” Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
108 citations,
July 2002 in “Molecular and cellular biology” Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.