research Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice
External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.
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research Vitamin D Metabolism and Function in the Skin
Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
research Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins
Human hair follicle dermal cells can effectively replace other cells in engineered skin.
research Stem Cells in Dermatology and Anti-Aging Care of the Skin
Using defensins to activate stem cells may improve skin aging signs without causing inflammation.
research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution
Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.
research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation
Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.
research Hair Follicle Regeneration Using Grafted Rodent and Human Cells
Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.
research Stem Cells and the Skin
Stem cells can rejuvenate skin, restore hair, and aid in wound healing.
research A Two-Step Culture Method for Efficient Production of Trichogenic Keratinocytes
A two-step method was created in 2015 to make more cells that help with hair growth, but they need to be combined with other cells for 4 days to actually form new hair.
research Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor
Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.
research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin
PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.
research Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit During Hair Cycle
COX-2 levels change during the hair cycle and affect skin and hair growth.
research In Vitro Methodology, Hormonal and Nutritional Effects, and Fiber Production in Isolated Ovine and Caprine Anagen Hair Follicles
Angora goat hair grows faster and produces more protein than cashmere goat hair, and certain hormones and nutrients positively affect hair growth and protein synthesis.
research RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development
RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.
research Integrin α3β1 in Hair Bulge Stem Cells Modulates CCN2 Expression and Promotes Skin Tumorigenesis
Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.
research Dynamics and Epigenetics of the Epidermal Differentiation Complex
Epigenetic mechanisms control skin development by regulating gene expression.
research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth
Vitamin D Receptor is crucial for normal skin and hair growth.
research Human Skin Stem Cells and the Aging Process
Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle
EGF controls hair growth by regulating hair follicles' growth phases.
research Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice
Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.
research Estrogen Functions in Skin and Skin Appendages
Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.
research 17β-Estradiol Inhibits the Production of RANTES in Human Keratinocytes
17β-estradiol can reduce inflammation in the skin.
research Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis
Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
research Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells
Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.
research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models
Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
research Endogenous Human Skin Equivalent Promotes In Vitro Morphogenesis of Follicle-Like Structures
Endo-HSE helps grow hair-like structures from human skin cells in the lab.
research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
research Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture
Skin cells can help create early hair-like structures in lab cultures.
research Vitamin D and Calcium Signaling in Epidermal Stem Cells and Their Regeneration
Vitamin D and calcium are important for skin stem cell function and wound healing.
research Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo
Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.