68 citations,
June 2005 in “Expert Opinion on Therapeutic Targets” Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.
61 citations,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
58 citations,
November 2013 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
56 citations,
March 2003 in “Journal of Investigative Dermatology” 17β-estradiol can reduce inflammation in the skin.
43 citations,
December 2008 in “Molecular biology of the cell” Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.
38 citations,
June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
36 citations,
May 2016 in “Biomaterials” Endo-HSE helps grow hair-like structures from human skin cells in the lab.
31 citations,
July 2017 in “Clinical Science” MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
18 citations,
January 2018 in “International journal of medical sciences” Non-thermal plasma treatment makes mouse skin thicker and increases growth factors without harming the tissue.
12 citations,
September 2020 in “Stem cell research & therapy” Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.
12 citations,
February 1997 in “British Journal of Dermatology” The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.
11 citations,
November 2015 in “Experimental Dermatology” The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.
10 citations,
June 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Scientists successfully grew new hair follicles in regenerated mouse skin using mouse and human cells.
10 citations,
November 2010 in “Pigment Cell & Melanoma Research” Only skin melanocytes, not other types, can color hair in mice.
8 citations,
January 2013 in “The scientific world journal/TheScientificWorldjournal” Human hair follicles may provide a noninvasive way to diagnose diseases and have potential in regenerative medicine.
5 citations,
May 2021 in “International Journal of Cosmetic Science” Healthy scalp leads to better hair quality and less damage.
2 citations,
April 2021 in “FEBS open bio” Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.
1 citations,
October 2022 in “Veterinary pathology” Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.
1 citations,
July 2016 in “Elsevier eBooks” Understanding skin structure and development helps diagnose and treat skin disorders.
1 citations,
April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
1 citations,
January 2012 in “Elsevier eBooks” The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.
1 citations,
December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Choosing the right method to separate skin layers is key for good skin cell research.
July 2021 in “British Journal of Dermatology” A woman with systemic sclerosis developed a unique scarring hair loss combining features of systemic sclerosis and frontal fibrosing alopecia.
Injecting a person's own skin cells back into their skin is a promising, safe, and affordable treatment for skin disorders.
October 2007 in “Journal of Investigative Dermatology” The meeting highlighted the genetic basis of female pattern hair loss and various skin health insights.
253 citations,
April 2008 in “Current opinion in cell biology” Notch signalling helps skin cells differentiate and prevents tumors.
211 citations,
November 2018 in “Nature Cell Biology” Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
195 citations,
January 2008 in “Photochemistry and Photobiology” Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.
179 citations,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
158 citations,
August 2011 in “Reviews in endocrine and metabolic disorders” Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.