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Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

Most people with basal cell carcinoma on their head or neck were 60-70 years old, and it often came back even after being fully removed, especially in certain areas and types.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

Vismodegib is effective for basal cell carcinoma but has severe side effects.

The research suggests new treatments for skin cancer could target specific cell growth pathways.

The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.

Looking at tissue characteristics isn't reliable for telling apart basal cell carcinoma from certain benign skin tumors.

Scalp basal cell carcinoma may be more aggressive and harder to treat than other types, requiring special attention and further research.

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

A small group of slow-growing cells causes basal cell carcinoma to return after treatment.

Aggressive scalp squamous cell carcinomas have a high death rate and need early, strong treatment.

The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.

The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.

External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.

Mouse skin cancer progression involves a unique group of cells marked by ABCG2 and MTS24.

A rare type of skin cancer on the scalp can be mistaken for hair loss, causing delayed diagnosis and severe damage.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

People with myotonic dystrophy type 1 tend to develop basal cell carcinoma at a younger age but not more frequently than others.

LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Mohs micrographic surgery is effective for early-stage non-melanoma skin cancers on the lips, with basal cell carcinoma more common on the upper cutaneous lip and squamous cell carcinoma more common on the lower vermilion lip.

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

Some aggressive scalp cancers are hard to treat and can be deadly, even when removed with specialized surgery.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.