18 citations
,
January 2021 in “Skin Research and Technology” This study found that high-frequency ultrasound was effective in localizing deep tumor margins in basal cell carcinoma, suggesting its utility in selecting therapeutic approaches.
18 citations
,
February 2017 in “Molecular Medicine Reports” This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.
18 citations
,
March 2011 in “Journal of The American Academy of Dermatology” Familial factors affect hair loss types in Koreans, with M type in men, L type in women, and paternal factors influencing male hair loss more.
18 citations
,
February 2001 in “Der Hautarzt” This case study of a 50-year-old woman with myotonic dystrophy and multiple basal cell carcinomas suggests there could be a genetic predisposition for certain cutaneous tumors in such patients.
17 citations
,
May 2019 in “Molecules” This study found that domestic temporary hair dyes may pose a health risk due to their cytotoxic effects on human red blood cells and NIH/3T3 cell lines.
17 citations
,
June 2017 in “British Journal of Dermatology” This review examines the interaction between hedgehog and Wnt/β-catenin signalling in hair follicles and basal cell carcinoma, linking Hh pathway inhibition to both tumor regression and alopecia.
17 citations
,
January 2010 in “PubMed” CD10 helps distinguish between basal cell carcinoma and benign hair follicle tumors.
16 citations
,
October 2012 in “The Journal of Dermatology” This study found that the BASP classification system for pattern hair loss showed better reproducibility and repeatability compared to the Norwood-Hamilton classification.
16 citations
,
January 2001 in “Clinical and Experimental Dermatology” Photodynamic therapy was effective in treating multiple scalp basal cell carcinomas with minimal side effects and good cosmetic results.
15 citations
,
October 2014 in “Journal of Investigative Dermatology” This review discusses the development of targeted therapies for basal cell carcinoma that interfere with Hedgehog signaling and reports no new research findings.
15 citations
,
September 2014 in “PloS one” This study found that HIF1 and mTORC1 signalling were active in both basal cell carcinoma and trichoepithelioma, but the pathways do not reliably differentiate between the two.
15 citations
,
December 2007 in “Dermatologic Therapy” This review discusses past hair transplantation techniques for androgenic alopecia and current research to improve results, but it reports no new clinical outcomes.
14 citations
,
May 2022 in “Cell Reports” In this study, researchers found that basal cell carcinomas with common Hedgehog signaling mutations may require additional mutations to hyperactivate downstream signaling and progress beyond dormancy.
14 citations
,
July 2021 in “Reviews in endocrine and metabolic disorders” This study explores how SARS-CoV-2 interacts with endocrine organs and highlights specific endocrine molecules that help explain the progression and outcomes of COVID-19, especially in patients with certain metabolic conditions.
14 citations
,
March 2016 in “Mechanisms of Development” This study found that BNC2 is critical for hair follicle regeneration and other developmental processes, as Bnc2−/− mice exhibit incomplete hair follicle development and developmental defects, and BNC1 cannot substitute for BNC2.
13 citations
,
June 2018 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study found that the expression of laminin-511 and -332 was significantly increased in psoriasis skin lesions and may influence keratinocyte proliferation and apoptosis, suggesting a previously overlooked role in the disease's pathogenesis.
13 citations
,
December 1983 in “Canadian journal of zoology” This study found that mesenchymal cell processes from the dermal papilla contact epithelial hair matrix cells through gaps in the basal lamina during hair matrix cell differentiation in mouse vibrissa follicles.
12 citations
,
June 2013 in “International Journal of Dermatology” This study found that different types of seborrheic keratosis demonstrate diverse differentiation patterns, highlighting its undifferentiated and hyperproliferative state with varying keratinization directions.
12 citations
,
January 1991 in “Acta Dermato Venereologica” The researchers reported that BCE-like changes overlying dermatofibroma show a differentiation pattern most similar to normal basal cells based on specific keratin markers.
11 citations
,
December 2018 in “Journal of Dermatology” This study found that finasteride 1 mg improved hair growth in 85.7% of Korean men with androgenetic alopecia over five years, with varying effectiveness depending on the type of hair loss.
11 citations
,
November 2018 in “British Journal of Dermatology” In this study, adults with persistent facial erythema of rosacea showed significantly greater improvement when treated with once-daily oxymetazoline cream compared to a vehicle, and using baseline photographs in assessments enhanced the accuracy by reducing perceived vehicle effects.
10 citations
,
June 2024 in “American Journal of Clinical Dermatology” This review highlights that while sonidegib and vismodegib offer promising treatment options for advanced basal cell carcinoma, their use is often limited by treatment-emergent adverse events, which can be managed through protocol modifications and supportive interventions.
10 citations
,
May 2016 in “Polymer” This study reports that novel core-ABS nanocarriers efficiently loaded with dexamethasone and finasteride show potential for dermal drug delivery, exhibiting non-toxic interactions with human keratinocyte cells and skin penetration.
10 citations
,
December 2015 in “International Journal of Dermatology” This study suggests that basal cell carcinoma and trichoblastoma may share differentiation toward the hair follicle, as indicated by strong positivity in CK 15, follistatin, and Bmi‐1 markers.
9 citations
,
January 2017 in “Virchows Archiv” This study documented distinct expression patterns of stem cell markers LGR5 and LGR6 in various human skin tumors, highlighting differences in their potential roles and contributions to tumor development.
9 citations
,
May 2022 in “Actas Dermo-Sifiliográficas” This study found that basal cell carcinoma exhibits altered expression patterns of CD10, p63, BCL-2, and EMA proteins compared to normal skin, with notable differences in staining and reactivity.
9 citations
,
May 2022 in “Drugs in Context” This report describes the successful use of sonidegib in treating two cases of locally advanced basal cell carcinoma, leading to remission in both instances, and reducing lesions in a patient with Gorlin syndrome, while noting mild side effects consistent with the drug's known profile.
9 citations
,
April 1999 in “Mammalian Genome” This study reports that the acidic and basic keratin gene clusters in dogs are located on chromosomes CFA9 and CFA27, respectively, similar to genetic arrangements in humans and mice.
8 citations
,
May 2019 in “Journal of dermatological treatment” This study found that vismodegib was effective in treating basal cell carcinoma, achieving complete remission in some patients; however, significant side effects often required careful management to prevent therapy suspension, which can lead to resistance.
8 citations
,
August 2016 in “Journal of pathology and translational medicine” This study found that CD99 is strongly expressed in the basal cells and hair follicles of normal adult and developing fetal skin, with expression patterns becoming similar after 20 weeks of gestation.