January 2023 in “Journal of cosmetic dermatology” This study found that the synthetic retinoid EC23 effectively induces keratinocyte hyperproliferation and enhances hair growth in mice, showing more potency than all-trans retinoic acid.
This review explores plant-derived exosomes as promising alternatives to synthetic wound-healing agents due to their ability to regulate signaling pathways involved in skin repair, while also addressing challenges in their clinical application.
228 citations
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June 2021 in “Frontiers in Immunology” This review discusses the role of macrophages in chronic wound healing and suggests that understanding their regulation can inform therapeutic approaches, but it reports no new results.
158 citations
,
August 2011 in “Reviews in endocrine and metabolic disorders” This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.
98 citations
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May 2010 in “British Journal of Dermatology” This document discusses the British Association of Dermatologists' current perspective on isotretinoin, focusing on its known side effects, prescribing requirements, teratogenic risks, and the contentious link to mood changes, reporting no new research findings.
45 citations
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December 2006 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” This review discusses the multifaceted role of vitamin D in the body, noting its influence on calcium balance, hair cycle maintenance, cell proliferation, cardiovascular function, and immune modulation, with no new clinical results reported.
37 citations
,
October 2021 in “Journal of Clinical Investigation” This study suggests that inflammation in the skin can exacerbate intestinal inflammation in inflammatory bowel diseases by activating fibroblasts in the colon through hyaluronan fragments released during skin inflammation.
22 citations
,
August 2021 in “Frontiers in medicine” This study found that monocytes/macrophages with a pro-inflammatory M1-like phenotype may play a crucial role in the pathogenesis of hidradenitis suppurativa, suggesting potential therapeutic targets.
13 citations
,
April 2019 in “iScience” In this study, researchers observed that EGFR deficiency in the epidermis affects gene expression related to cell differentiation and structure, highlighting spatial and temporal roles of EGFR during skin and hair follicle development.
8 citations
,
October 2022 in “Biomedical Materials” This study found that incorporating hair follicle-primed spheroids into skin constructs showed potential for developing hair-bearing skin mimetics with follicle-forming abilities in vitro.
6 citations
,
May 2019 in “Journal of pharmaceutical sciences” This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.
1 citations
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July 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses various topics from the 62nd Annual Montagna Symposium on the Biology of Skin, focusing on the diverse effects of light on skin biology, and reports no new clinical results.
February 2026 in “Cosmetics” This study found that upcycled postbiotic cell-free supernatants from Limosilactobacillus fermentum MG901 and MG4237 protected human dermal papilla cells from oxidative stress, enhancing wound-healing capacity and mitochondrial function, suggesting potential as a sustainable cosmetic ingredient for hair loss alleviation.
January 2025 in “Journal of Controlled Release” This study developed a gas-propelled microneedle patch with puerarin/quercetin nanoparticles, which demonstrated improved hair-regenerating effects in an androgenetic alopecia mouse model by increasing drug delivery, alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells.
March 2024 in “International journal of molecular sciences” This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.
September 2023 in “Gynäkologische Endokrinologie” This review discusses how the hormonal changes of menopause affect skin and hair, highlighting improvements in skin symptoms like dryness and reduced wound healing with estrogen supplementation, and advises healthcare providers to consider broader potential benefits of menopausal hormone therapy when consulting patients.
November 2019 in “Harper's Textbook of Pediatric Dermatology” This article reviews Netherton syndrome, focusing on its genetic basis, clinical presentation, and treatment options, and reports no clinical results; the authors mention potential benefits of targeted therapies and gene therapy.
January 2024 in “Biomaterials Research” This study found that human hair follicle dermal papilla cells cultivated as 3D spheroids in hexanoyl glycol chitosan-coated dishes formed hair-like structures, with minoxidil enhancing growth, and successfully integrated into artificial skin models, suggesting advancements for hair loss treatments and skin restoration therapies.
2 citations
,
May 2024 in “Journal of science and medicine in sport” This position statement reviews the role of exercise professionals in managing PCOS and provides recommendations for physical activity, but it reports no new clinical findings.
June 2021 in “Health and Society” In this study, lifestyle changes, particularly weight loss, were reported to improve symptoms and prognosis of Polycystic Ovary Syndrome, especially in patients who are overweight or obese.
65 citations
,
December 2000 in “PubMed” This article reviews key questions in skin biology, particularly the mechanisms of hair follicle patterning and the role of stem cells in the epidermis, reporting no new results.
11 citations
,
July 2022 in “International Journal of Molecular Sciences” This study found that treating reconstructed human epidermis with beta-lipohydroxy salicylic acid increased tight junction remnants in the stratum corneum, potentially affecting skin cohesion and desquamation.
4 citations
,
October 2024 in “International Journal of Molecular Sciences” In this study, topical naringin was found to significantly improve dermatitis severity and reduce inflammatory markers in a mouse model of atopic dermatitis, suggesting its potential as a therapeutic agent for this condition.
3 citations
,
January 2021 in “FEBS open bio” This study found that a solution containing 0.5% Camellia japonica placenta extract increased scalp moisture and reduced sebum content, dead keratin, and erythema in adult females, suggesting potential as a scalp treatment.
1 citations
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January 2025 in “Molecules” This review reported that while glycyl-L-histidyl-L-lysine tripeptide copper complex (GHK–Cu) has limited skin permeation when used alone, liposomes may enhance its absorption, but there is limited research on this aspect, highlighting a need for further studies.
November 2025 in “Journal of Investigative Dermatology” TEDAR is crucial for skin cell differentiation and barrier formation.
November 2025 in “Dermato” In this review, researchers synthesized contemporary findings about the human skin microbiome's influence on conditions like acne, aging, and hyperpigmentation, highlighting the potential of microbiome-informed strategies and treatments such as postbiotics and probiotics to improve dermatological outcomes.
October 2025 in “Journal of Investigative Dermatology” This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.
January 2025 in “International Journal of Molecular Sciences” This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.
August 2023 in “Processes” This study found that fermenting Dendrobium officinale with Lactiplantibacillus plantarum CCFM8661 and other strains increased polysaccharide yields and skin care activity, particularly with CCFM8631, which showed significant improvements in skin cell protection and inflammation reduction in both cell cultures and mouse models.