17 citations
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January 2011 in “The Korean Journal of Hepatology” This case report details an occurrence of Vogt-Koyanagi-Harada disease during pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C.
7 citations
,
January 2002 in “PubMed” This study observed significant skin changes, including epidermal thickening and pleomorphic keratinocytes, in rats after subchronic UVB irradiation, highlighting specific reactions in the dorsal skin.
6 citations
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June 2017 in “Asian journal of beauty & cosmetology” In this study, Rosa multiflora root extracts showed strong antioxidant activity and promoted expression of growth factors IGF1 and PDGFB, suggesting potential use as a natural hair growth agent.
4 citations
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May 2022 in “International journal of molecular sciences” This study found that heat-killed Enterococcus faecalis EF-2001 promoted hair regrowth in mice, likely by increasing the expression of growth factors and marker genes.
August 2026 in “Molecular and Cellular Biochemistry” This study found that administering tolerogenic dendritic cell-conditioned medium to dihydrotestosterone-treated mice promoted hair regrowth by modulating the follicular microenvironment, reducing pro-inflammatory cytokines, and activating key signaling pathways, highlighting its potential as a treatment for androgenetic alopecia.
August 2023 in “Journal of Cosmetic Dermatology” This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.
January 2019 in “Proceedings for Annual Meeting of The Japanese Pharmacological Society” In this study, injecting Nε-(carboxymethyl) lysine into skin tissue weakened hair shaft and follicle formation, likely by inhibiting cell proliferation and migration needed for hair follicle morphogenesis.
November 2022 in “Journal of Investigative Dermatology” This study found that a lotion containing specific plant extracts significantly increased the number of anagen hairs and the anagen/telogen ratio in subjects with androgenetic alopecia after three months of use.
7 citations
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December 2019 in “Experimental and Therapeutic Medicine” This study examined the effects of WNT10B on dermal papilla cells in vitro, finding that it alters gene expression, decreases protein synthesis, and upregulates a specific signaling pathway, potentially influencing hair follicle morphogenesis.
1 citations
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January 2025 in “Regenerative Biomaterials” In this study, researchers found that exosomes derived from Pinctada martensii mucus can effectively inhibit melanin production in melanoma cells and zebrafish without adverse effects, potentially offering a promising therapeutic strategy for treating pigmentary disorders by modulating the NF-κB signaling pathway.
February 2024 in “Molecules/Molecules online/Molecules annual” In this study, NMN was found to reverse hair follicle atrophy, thinning, and sparsity in mice induced by DHT, and significantly decreased DHT-induced inflammation and oxidative stress in cultured human dermal papilla cells, enhancing hair growth-related markers.
September 2017 in “Journal of Investigative Dermatology” This study found that mackerel fermented fish oil protected human keratinocyte cells from UVB-induced oxidative stress by scavenging free radicals and reducing cellular damage.
March 2011 in “Open Archive (Karolinska Institutet)” This study explored the effects of a common Hutchinson-Gilford progeria syndrome mutation in an inducible mouse model, revealing skin abnormalities similar to those in affected patients.
This study found that in mice, the combination of azelaic acid and vitamin B6 enhanced hair regrowth, follicle elongation, and thickness more than individual treatments.
54 citations
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June 2008 in “Planta Medica” This study found that hinokitiol effectively suppressed TNF-α production in activated macrophage-like cells, suggesting it may help alleviate hair loss by mitigating factors that promote follicular apoptosis.
February 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that in a human skin organ culture model of pemphigus vulgaris, split formation led to significant upregulation of IFNγ and TNFα-related genes, indicating secondary effects from mechanical stress, not direct changes from autoantibodies.
In this case study, a 19-year-old woman with Henoch-Schönlein purpura, potentially triggered by hepatitis B vaccination, experienced improved symptoms after correcting low vitamin D levels and undergoing tonsillectomy, demonstrating these interventions may benefit similar patients.
14 citations
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June 2018 in “Frontiers in pharmacology” In this study, EGCG from green tea promoted mink hair follicle growth and cell proliferation at specific concentrations, potentially through activation of Shh and AKT signaling pathways.
This study found that Heated radish extract potently suppressed melanin production in vitro and reduced wrinkle formation and collagen degradation in vivo, suggesting its potential as a skin whitening and antiaging product.
125 citations
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August 2020 in “Frontiers in Immunology” This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.
80 citations
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June 2000 in “Modern Pathology” Long-standing benign tumors can become cancerous, especially in people with weakened immune systems.
59 citations
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June 2022 in “Frontiers in medicine” This review discusses the complex causes and treatment challenges of chronic inflammatory skin diseases, emphasizing the need for biomarkers to predict treatment responses; it reports no new clinical results.
58 citations
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April 2012 in “Journal of the American Academy of Dermatology” Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.
45 citations
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October 2018 in “JCI Insight” In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.
17 citations
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June 2016 in “Croatian Medical Journal” In this study, vitiligo and alopecia areata were more common among patients with chronic graft-vs-host disease than previously reported, linked to higher NIH skin scores and greater immunosuppressive treatment.
17 citations
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May 2011 in “Gene Therapy” This study found that transfecting hair follicle stem cells with a PEI-DNA complex expressing hTERT stimulated hair growth in rats by inducing follicle neogenesis and promoting the anagen phase.
16 citations
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March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.
13 citations
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September 2022 in “Biomolecules” This study found that specific gene upregulations and mutations in hidradenitis suppurativa skin support the role of inflammation, altered epithelial differentiation, and metabolism dysregulation in the disease's pathogenesis.
9 citations
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January 2018 in “Acta Clinica Croatica” This review suggests that bendamustine, alone or in combination, shows effectiveness in treating indolent non-Hodgkin lymphoma and chronic lymphocytic leukemia, with recent studies highlighting its benefits especially in combination therapies, while balancing efficacy with a favorable toxicity profile.
5 citations
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February 2022 in “Seminars in cell & developmental biology” This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.