July 2026 in “Journal of the American Academy of Dermatology” CRT is more effective than oral minoxidil alone for treating hair loss.
April 2026 in “Journal of Cosmetic Dermatology” The article "Clinical Efficacy and Mechanisms of Microneedling Alone or Combined With Drugs in the Treatment of Androgenetic Alopecia" has been retracted due to concerns about the validity of several cited references, which were found to be invalid or non-existent. The authors failed to provide correct DOIs and links, leaving several statements unsupported. Additionally, there were concerns about the possible use of AI-generated content without proper review. Despite the authors' disagreement, the retraction was agreed upon by the journal's Editor-in-Chief and Wiley Periodicals, LLC.
February 2026 in “Journal of Cosmetic Dermatology” This study found that microneedling, alone or combined with drugs, was effective in reducing hair loss severity and increasing hair density in male androgenetic alopecia patients, with the combination therapy showing more significant results for moderate to severe cases.
July 2025 in “Journal of the Pakistan Medical Association” In this study, intralesional triamcinolone acetonide combined with 5-fluorouracil was more effective for treating keloids, showing a good to excellent response in 95% of cases and fewer side effects, compared to triamcinolone acetonide alone, which achieved a 70% response rate.
This study observed that a combination treatment of 2% topical minoxidil and oral vitamin D significantly improved hair density and vitamin D levels in women with female pattern hair loss, compared to minoxidil or vitamin D used alone.
January 2025 in “Lasers in Medical Science” In this study, researchers found that combining fractional CO2 laser sessions with topical dutasteride was more effective in improving male androgenic alopecia than using the laser treatment alone, as observed through global photo assessments and dermoscopic parameters.
In this study, among 30 patients with androgenetic alopecia, topical Minoxidil was effective alone or in combination with either oral or microneedling-applied Dutasteride, with the microneedling approach offering promising results and fewer side effects compared to oral Dutasteride.
June 2024 in “Journal of Ayub Medical College Abbottabad” This study concluded that adding 5% topical Procapil to PRP therapy provided better outcomes for androgenetic alopecia than PRP alone, as assessed by dermatologist evaluations and patient satisfaction.
January 2024 in “Photodiagnosis and Photodynamic Therapy” The study found that combining a 655nm low-level laser helmet with 2% minoxidil resulted in better improvement in hair diameter and intermediate hair enlargement at the midscalp among Chinese women with FPHL.
June 2023 in “QJM: An International Journal of Medicine” This study found that combining fractional CO2 laser treatment with platelet-rich plasma led to a statistically significant improvement in hair regrowth for male androgenetic alopecia, compared to using the laser treatment alone.
In this study, minoxidil combined with PRP was found to effectively increase hair density in women with female pattern hair loss, but showed no superiority over minoxidil alone. No major side effects were reported.
April 2022 in “Research Square (Research Square)” In this study, both topical clobetasol propionate and fractional Er: YAG laser followed by topical steroids demonstrated significant improvement in patients with alopecia areata, but the combined laser and steroid treatment was found to be more effective and safe.
March 2020 in “QJM: An International Journal of Medicine” This study found that intradermal minoxidil 5% alone and with intralesional triamcinolone acetonide significantly reduced alopecia areata dermoscopic findings, while standard intralesional corticosteroids remain the main first-line treatment for patchy alopecia with less than 50% scalp involvement.
May 2021 in “IP Indian journal of clinical and experimental dermatology” This study found that combining topical 5% minoxidil with autologous PRP therapy significantly increased hair density in men with androgenetic alopecia compared to minoxidil alone, without major side effects.
In this study, a combination of GFM-lotion with autologous PRP treatment improved efficacy in treating androgenic alopecia compared to PRP alone, as shown by significant improvements in clinical assessments over 3 months.
56 citations
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December 1990 in “Differentiation” Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.
36 citations
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November 1995 in “Clinical endocrinology” This study found that a low dose of flutamide, both alone and combined with an oral contraceptive, effectively reduced hirsutism in women, with the combination showing more lasting effects post-treatment.
34 citations
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May 2017 in “Lasers in Surgery and Medicine” This study found that combining low-level light therapy with topical minoxidil 5% may lead to better hair regrowth and patient satisfaction in treating female pattern hair loss compared to using each treatment alone.
33 citations
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April 2015 in “Cochrane library” This review examined various treatments for hirsutism and found low to very low quality evidence suggesting that flutamide and spironolactone may help reduce hair growth, while metformin was ineffective.
30 citations
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February 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This review found moderate to very low-quality evidence that spironolactone, flutamide, and cyproterone acetate combined with oral contraceptives may reduce hirsutism more effectively than placebo or metformin, though results vary among other treatments.
24 citations
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May 2013 in “Drug Design Development and Therapy” This pilot study found that a multimodal minoxidil microemulsion with diclofenac and tea tree oil was more effective and safer than minoxidil alone for treating androgenic alopecia over 32 weeks.
12 citations
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June 2018 in “Journal of Cosmetic Dermatology” This review outlines recent research on platelet-rich plasma, alone or combined with other therapies, for managing hair loss disorders, and discusses future prospects without reporting new clinical findings.
10 citations
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June 2019 in “Dermatologic therapy” In this study, treatment with DPCP alone was more effective for hair regrowth and presented fewer side effects in chronic extensive alopecia areata compared to combination therapy with DPCP and anthralin.
9 citations
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January 2019 in “International Journal of Trichology” In this study, combining topical calcipotriol with mometasone results in greater improvement in alopecia areata treatment compared to using mometasone alone, as evidenced by a more significant reduction in SALT score over 24 weeks.
9 citations
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April 2016 in “Australasian journal of dermatology” This study suggests that adding imiquimod to diphenylcyclopropenone treatment significantly improves outcomes for alopecia areata patients who initially do not respond to diphenylcyclopropenone alone.
8 citations
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March 2022 in “International Journal of Endocrinology” This study found that combining low-dose spironolactone with metformin improved insulin resistance in PCOS patients more effectively than using either drug alone.
7 citations
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August 2019 in “American Journal of Dermatopathology” This study found that limb hair loss in frontal fibrosing alopecia is inflammatory and permanent, but lacks the classic scarring features seen in scalp alopecia, prompting potential misdiagnosis as alopecia areata.
6 citations
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November 2010 in “International Journal of Andrology” In a clinical trial, this study found that a modified slow-release oral testosterone formulation improved pharmacokinetics, delaying serum testosterone peaks and reducing serum DHT compared to immediate-release formulations, especially when combined with finasteride.
3 citations
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January 2025 in “Journal of Research in Medical Sciences” This study reported that among obese women with PCOS, neither early time-restricted eating (eTRE) alone nor combined with probiotics showed significant improvements in blood pressure, inflammatory markers, oxidative stress, or antioxidant capacity compared to a standard reduced-calorie diet.
2 citations
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September 2024 in “PLoS ONE” This study suggests that combining bendamustine with tucidinostat may improve survival in patients with relapsed or refractory adult T-cell leukemia/lymphoma, highlighting its potential for clinical investigation.