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This article discusses the association of stressful life events with alopecia areata and their effects on patients' psychosocial outcomes, but it reports no new empirical findings.

Alopecia areata may involve stress-related changes affecting hormone receptors, leading to reduced cortisol production.

This study examined the expression patterns of various cytokeratins in the outer root sheath of human anagen hair follicles, noting distinct differentiation patterns and localization of keratin markers.

This review summarizes the association between 5-alpha reductase inhibitors and depression, discussing potential mechanisms such as neuroactive steroid alterations and neuroinflammation, but reports no new clinical results.

This study discusses hormonal changes in gastroesophageal reflux disease that may affect sebaceous gland secretion but does not report new clinical results, suggesting a need for collaborative research in gastroenterology and dermatology.

This case series reported incidents of iatrogenic Cushing's Syndrome linked to high doses of intralesional corticosteroid injections and mesotherapy regimens, highlighting the need for cautious prescription practices and further research on mesotherapy safety.

This study found that women with PCOS had significantly higher hair cortisol concentrations, suggesting hyperactivation of the HPA axis may affect metabolic and inflammatory markers in those with elevated cortisol levels.

This article reviews how the skin's peripheral stress response system mirrors the central HPA axis, facilitating local homeostasis under stress, but presents no new findings.

This review discusses the role of microglia in mediating prenatal androgen effects on the female brain, potentially contributing to PCOS development and neuroendocrine dysfunctions, but reports no new results.

This research suggests that autism's genetic links are partially related to factors influencing physiological sex differences, with rare variants interacting with placental sex differences and common variants affecting steroid-related traits.

Women's hair has more sulfur, and black hair has more calcium than white hair.

This study explores the potential of adaptogenic herbal extracts like ashwagandha, rhodiola, and schisandra in treating stress-induced dermatoses, noting their effects on modulating the HPA axis, reducing inflammation, and improving skin barrier function.

The researchers reported that integrating the naturopathic complex Detoxil into standard therapy for chronic dermatoses enhances detoxification, normalizes metabolic markers, and accelerates symptom resolution, suggesting potential benefits for managing skin conditions.

This study found a partial positive association between adulthood stressor exposure and hair cortisol levels, but noted inconsistent results across two studies, reflecting variability seen in previous research.

In this study, pre-treatment with 5-α-reductase inhibitors (finasteride/dutasteride) in patients with metastatic renal cell carcinoma was associated with better immune checkpoint inhibitor effectiveness and improved progression-free and overall survival, without increasing severe side effects.

This review reports that alopecia, particularly alopecia areata, significantly impacts mental health and quality of life through stress and immune mechanisms, with treatments like Janus kinase inhibitors showing promise for improving both hair regrowth and psychological well-being.

This review found significant psychosocial impacts of alopecia, noting that those with alopecia, particularly alopecia areata, experience higher rates of depression and anxiety. The review also highlighted new treatments like Janus kinase inhibitors that improve both hair regrowth and quality of life.

This integrative literature review revealed that chronic stress, characterized by elevated cortisol levels, negatively impacts hair follicle integrity and contributes to alopecia by promoting the premature transition from the growth phase to the resting phase of the hair cycle.

This study systematically reviewed literature on paradoxical reactions during biologic treatments for psoriasis, identifying immune dysregulation mechanisms and diverse clinical manifestations, highlighting that mild cases often respond well to topical treatments, while severe cases may require switching to different IL-23 inhibitors.

This study reported that NLRP3 plays complex roles in wound healing by initially promoting inflammation and delaying repair, but later enhancing structural restoration through distinct signaling pathways, highlighting its potential as a therapeutic target for controlling inflammation and regeneration phases.

This study found that individuals with a recent history of suicide attempts exhibited altered DHEA hair levels, suggesting possible dysregulation of the HPA axis as a biopsychosocial feature, and recommends further investigation into hair hormones as potential markers of suicidal crisis and vulnerability.

In this review, researchers examined the concentration of cortisol in scalp hair of individuals with alopecia areata to explore its relationship with disease variables, as cortisol in hair can indicate chronic stress, which may impact alopecia areata pathogenesis.

This study reviewed literature on hair growth and found that external factors like pollution, stress, and nutrition can adversely affect hair, concluding that a multifactorial approach and personalized nutrition monitoring are essential for effective hair loss therapy.

This report describes two cases of glucocorticoid resistance syndrome highlighting genetic diversity; one patient improved with low-dose dexamethasone despite negative genetic testing, while the other is monitored with a novel NR3C1 variant.

This study outlines a multidisciplinary approach to investigate primary amenorrhea, emphasizing the necessity to consider medical history, physical examination, and potential hormonal or anatomical causes, and recommends early referral in cases of chromosomal abnormalities or persistent amenorrhea following the development of secondary sexual characteristics.

This study found that tildacerfont treatment in males with congenital adrenal hyperplasia reduced androgen levels and improved markers of testicular function, suggesting potential benefits for male reproductive health.

This article reviews the use of hair cortisol concentration as a biomarker to assess long-term stress in both animals and humans, but it reports no new experimental results.

This case study suggests that long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency, warranting further investigation.

This study highlights that stress-induced activation of the HPA axis in human hair follicles can lead to hair growth arrest, but variability in follicle response complicates potential therapeutic approaches.

This review discusses the role of neuroactive steroids in physiological processes and their potential involvement in neuropsychiatric disorders, but it reports no new experimental findings.