Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, researchers found that Hdac1 and Hdac2 are crucial for maintaining the quiescence and survival of dermal papilla cells in the hair follicle, regulating the hair cycle by controlling cell-cycle genes and Wnt signaling.

This study found that Dermal Fibroblast Progenitors have repressed chromatin profiles which hinder their ability to reform skin in allograft assays despite their differentiation potential.

This review discusses the genetic basis of ectodermal dysplasia, highlighting that identification of gene pathologies enhances diagnosis and supports prenatal DNA testing, but it reports no new clinical results.

This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.

This review highlights the roles of key transcription factors and signaling pathways in regulating olfactory epithelium regeneration, discussing recent advances in single-cell and spatial transcriptomics as well as organoid models to enhance understanding of olfactory regeneration mechanisms.

This research reports that the polyG fragment within the Hoxc13 protein alters its gene regulatory functions, which could have influenced mammalian hair evolution by affecting pathways related to hair follicle development.

In a hamster model of COVID-19, this study observed that both low and high doses of testosterone worsened illness in males, while finasteride prevented severe outcomes.

This review summarizes the role of G-protein-coupled receptors in wound healing and reports no new clinical results, highlighting their importance in signaling pathways and recent discoveries in their functions.

This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.

This review discusses the potential impact of lifestyle factors on the progression of androgenetic alopecia and reports no new clinical findings; the authors emphasize the need for more comprehensive studies.

In this study, the authors explored the role of Lgr5+ hair follicle stem cells and their regulation through the Wnt/-catenin pathway, highlighting how precise modulation of this pathway is crucial for treating hair loss safely and effectively.

This study found that exosomes derived from human amniotic mesenchymal stem cells enhanced stem cell proliferation and structural restoration in irradiated salivary glands of rats, with significant improvements observed by day 7, suggesting activation of the Wnt signaling pathway.

In this study, researchers developed an optimized formulation of a traditional ethnomedicinal recipe from East Nusa Tenggara, which demonstrated strong antioxidant activity and significantly enhanced hair growth in a mouse alopecia model, compared to control groups.

This study reports that in Rex rabbits, age affects fur quality and hair follicle traits, with the Wnt signaling pathway playing a role in their periodic hair follicle development.

This thesis investigates the underlying mechanisms and treatment options for androgenetic alopecia, highlighting the molecular roles of androgens and genetic predispositions, and evaluates current and emerging therapies, such as PROTACs and Janus Kinase inhibitors, to enhance patient management.

This study reviewed literature on signaling pathways and concluded that these pathways are crucial pharmacological targets, influencing the mechanisms of drugs used in neurological, cardiovascular, and oncological treatments to correct signal transmission disturbances.

In this study, researchers observed that individuals with alopecia areata exhibited significant changes in scalp microbiota diversity and composition, which were linked to disease severity and inflammation markers, though it remains unclear if these microbial shifts are a cause or a result of hair loss.

This study examines the role of hair follicle stem cells in epidermal regeneration during skin soft tissue expansion, proposing a potential method for their cellular and molecular regulation.

This review explores the complex interactions of intrinsic and extrinsic mechanisms that regulate hair follicle stem cells and their role in skin homeostasis, aiming to advance understanding that could support future research on skin disorders.

This study found that 12.5% moringa seed oil demonstrated optimal anti-alopecia activity in rabbits, significantly improving hair weight compared to the treatment with 0.1% finasteride.

This review investigates molecular mechanisms behind PCOS pathogenesis and discusses potential therapies, but reports no new clinical results.

This study found that maintaining a low level of Wnt/β-catenin activity is crucial for mammary gland development, as excessive activity inhibits branching and promotes characteristics of hair follicles instead, highlighting its role in skin appendage identity decisions.

This review examined moringa seed oil's potential to combat alopecia, reporting that its phytosterol and fatty acid compounds may block dihydrotestosterone formation and support healthy hair growth.

This genetic study identified a potential interval for the Marie Unna hypotrichosis gene but found no mutations in the nearby hr gene, suggesting its involvement remains unconfirmed.

This study found that strontium ranelate may promote cartilage regeneration by enhancing chondrogenic differentiation and inhibiting the Wnt/β-catenin signaling pathway in rat models of cartilage defects.

The study found that dermal EZH2 plays a crucial role in coordinating dermal fibroblast differentiation and epidermal development by modulating Wnt/β-catenin and retinoic acid signaling.

This study found that the Polycomb Repressive Complex 2, particularly its component Ezh2, is crucial in regulating dermal fibroblast differentiation and epidermal keratinocyte proliferation during murine skin development.

This review discusses natural remedies and nanoparticle formulations for alopecia management and reports no new clinical results, emphasizing potential benefits of herbal treatments over synthetic therapies.

The review discusses the diverse roles of WNT10B in mammary gland development, immune function, and its potential implications in cancer and regenerative processes, with no new experimental results.

This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.