research DNN-DTIs: Improved Drug-Target Interactions Prediction Using XGBoost Feature Selection and Deep Neural Network
The DNN-DTIs method accurately predicts drug-target interactions and is useful for drug repositioning.
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research A Powerful Method for Pleiotropic Analysis Under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate Cancer
The new method found new shared genetic areas linked to both Type 2 Diabetes and Prostate Cancer.
research Biological Insights from Self-Perceived Facial Aging Data of the UK Biobank Participants
Self-perceived facial aging is linked to skin pigmentation, immune system, hair loss in men, and genes related to the skin's structure.
research GTL1 Is Required for a Robust Root Hair Growth Response to Avoid Nutrient Overloading
GTL1 is needed to control root hair growth and prevent problems when there are too many nutrients.
research NAC Transcription Factor RD26 Is a Regulator of Root Hair Morphogenic Plasticity
RD26 controls root hair growth during drought by repressing key genes, helping plants save energy.
research Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision Between Stem Cell Maintenance and Differentiation
Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.
research Polyamine-Controlled Proliferation and Protein Biosynthesis Are Independent Determinants of Hair Follicle Stem Cell Fate
Polyamines are important in deciding hair follicle stem cell behavior, affecting hair growth and loss.
research New Technologies for Hair Follicle Growth and Regeneration: Comparison Between Different Commercial Products Containing Exosomes
Exosomes from bovine colostrum may be effective for hair growth and slowing hair loss.
research Wound-Initiated Hair Regeneration by Adhesive and Shrinkable Materials
A new method using special materials can help regrow hair by creating small wounds.
research Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice
Hair loss in certain mice is linked to changes in keratin-related genes.
research Targeting PrfA From Listeria Monocytogenes: A Computational Drug Repurposing Approach
The research suggests Dutasteride and Solifenacin may be effective against the bacterium causing listeriosis.
research Partial Alopecia Area Retains Bulge Hair Follicle Progenitor Cells in Indian Androgenetic Alopecia Patients
Some hair growth cells remain in partially bald areas of Indian men with hair loss.
research Gatekeeping the Sebaceous Gland
The research found that specific stem cells maintain skin gland openings and that disrupting their activity can cause blockages or early cancer signs, indicating a need for targeted treatments.
research TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling
TLR2, a component in hair follicle stem cells, is crucial for healthy hair growth and regeneration, and its decrease can lead to hair loss.
research Remodelling of Cytoskeleton and Plasma Membrane Proteins Contributes to Drought Sensitivity of Arabidopsis Rhd2 Mutant
The Arabidopsis rhd2 mutant is more sensitive to drought because of changes in cell membrane proteins and cell structure.
research Witnessed Trauma Exposure Induces Fear in Mice Through a Reduction in Endogenous Neurosteroid Synthesis
Seeing trauma causes fear in mice by lowering their natural fear-reducing hormones.
research Telocytes Are a Critical Source of Wnts Essential for Hair Follicle Regeneration
Telocytes, cells with long extensions, are vital for hair growth because they produce Wnt signals, which are necessary for hair follicle regeneration.
research Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation
The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.
research Mediator 1 Ablation Induces Enamel-to-Hair Lineage Conversion Through Enhancer Dynamics
Removing Mediator 1 causes teeth cells to turn into hair cells.
research An ERK-Dependent Molecular Switch Antagonizes Fibrosis And Promotes Regeneration In Spiny Mice (Acomys)
A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.
research 4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression
4-aminopyridine helps skin wounds heal faster and better.
research Non-Canonical Wnt Signaling Promotes Directed Migration of Intestinal Stem Cells to Sites of Injury
Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.
research Glutamic Acid Promotes Hair Growth in Mice
Glutamic acid helps mice grow hair.
research No Relationship Between Perceived Health Anomalies and Perceived Experimental Success in Retired Breeder Male Hartley Albino Guinea Pigs
Health issues in retired breeder guinea pigs don't affect experiment success.
research A Machine Learning and Network Framework to Discover New Indications for Small Molecules
The model successfully predicted new uses for existing drugs, like using certain hormonal and heart medications for respiratory and Parkinson's diseases, and a cancer drug for diabetes.
research Characteristic Localization of Neuronatin in Rat Tissues
Neuronatin is found in various cells of rat tissues and has a unique location in sperm cells.
research A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle
Endoglin is important for proper hair growth cycles and stem cell activation in hair follicles.
research M-CSF-Stimulated Myeloid Cells Can Convert Into Epithelial Cells to Participate in Re-Epithelialization and Hair Follicle Regeneration During Skin Wound Healing
Myeloid cells can turn into skin and hair cells to help heal wounds.
research Isolation of Sensory Hair Cell Specific Exosomes in Human Perilymph
research Cutaneous Changes During Pregnancy
Skin changes during pregnancy are common.