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Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Exosomal miRNAs from stem cells can help improve skin health and delay aging.

miRNA-based therapies show promise for treating skin diseases, including hair loss, in animals.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Epidermal growth factor helps stem cells heal wounds and regenerate hair follicles faster.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Placental mesenchymal stem cells and their conditioned medium significantly improve healing in local radiation injuries.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

Stem cell niches support, regulate, and coordinate stem cell functions.

Blood stem cells are diverse, influenced by many factors, and understanding them is key for progress in regenerative medicine.

Targeting lipid metabolism can help treat advanced, resistant cancers.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

Genes linked to wool fineness in sheep have been identified.

Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.

Different types of stem cells and their environments are key to skin repair and maintenance.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Young HS patients often have other physical and mental health issues, and research on HS covers a wide range of topics including genetics, triggers, treatments, and the need for more data.

Cell therapy shows promise for treating severe psoriasis but needs more research to confirm safety and effectiveness.

Stem cell-derived conditioned medium is effective in improving hair density and thickness for alopecia treatment.

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

Using a patient's own fat tissue helped treat hair loss caused by an injury.

Mesenchymal stromal cell therapies show promise for treating various diseases but need more research and standardization.