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Aging causes changes in scalp cells that can negatively affect hair health.

Minoxidil didn't significantly increase hair growth in minipigs.

GATA6 is important for maintaining and differentiating cells in a key area of human skin.

TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Minoxidil sulfate stimulates hair growth.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Oral minoxidil promotes hair growth but may cause side effects; needs monitoring.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.