140 citations
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December 2017 in “Journal of Controlled Release” This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
124 citations
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July 2012 in “Archives of Dermatological Research” This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.
73 citations
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October 2009 in “Anti-Cancer Agents in Medicinal Chemistry” This study found that new curcumin analogues, such as ASC-J9, can inhibit prostate cancer cell growth by promoting androgen receptor degradation.
69 citations
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October 2014 in “Stem Cells” This study found that PDGF-D acts as a potent mitogenic factor in adipose-derived stem cells, enhancing their proliferation, migration, and growth factor expression, suggesting its use as a preconditioning agent for ASC transplantation.
60 citations
,
June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
59 citations
,
August 2014 in “International Journal of Biological Macromolecules” In this study, the researchers optimized the extraction conditions for crude polysaccharide from Hibiscus rosa-sinensis leaves, achieving a yield of 9.66% and demonstrated strong antioxidant activities in vitro.
55 citations
,
May 1970 in “New England Journal of Medicine” This study found that scurvy is associated with the development of Sjögren's syndrome symptoms, which resolved with ascorbic acid repletion.
53 citations
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April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.
47 citations
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September 2023 in “Pharmacological Reports” In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.
43 citations
,
June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.
42 citations
,
February 2014 in “Stem Cells and Development” This study found that vitamin C increased the survival, proliferation, and hair-regenerative potential of adipose-derived stem cells through the MAPK pathway and enhanced hair growth in mice.
41 citations
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July 2012 in “Stem Cells and Development” This study found that low-dose UVB radiation enhances the survival, migration, and hair growth-promoting capacity of adipose-derived stem cells in mice through the generation of reactive oxygen species.
35 citations
,
January 2014 in “Journal of Tissue Engineering” This review discusses recent advances in the role of dermal papilla cells and adipocyte lineage cells in hair regeneration, but it reports no new clinical results.
29 citations
,
March 2020 in “Stem Cell Research & Therapy” This study suggests that adipose-derived mesenchymal stem cells from diabetic mice can enhance wound healing by promoting fibroblast growth, migration, angiogenesis, and differentiation into fibroblasts and endothelial cells.
24 citations
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July 2015 in “International Journal of Molecular Sciences” In this study, fluoxetine was found to decrease proliferation and adipogenic differentiation of human adipose-derived stem cells, suggesting it may reduce fat accumulation by increasing autophagy-related gene expression.
21 citations
,
July 2020 in “Stem Cell Research & Therapy” This study found that adipose-derived mesenchymal stem cells from type 2 diabetes mice were slightly less effective, yet had comparable therapeutic effects on wound healing compared to non-diabetic controls.
20 citations
,
December 2019 in “International Journal of Molecular Sciences” This study found that preconditioning adipose-derived stem cells with HB-EGF enhanced their ability to promote hair growth in vivo by increasing their motility, paracrine effects, and survival.
18 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This review found that existing studies on adipose tissue for scarring, wound healing, and hair growth show some positive outcomes, but the evidence is insufficient to change current dermatological practices.
18 citations
,
May 2018 in “International Journal of Molecular Sciences” In this study, adipose-derived stem cells from superficial adipose tissue showed higher regenerative potential, and more macrophages were found in superficial than deep adipose tissue, potentially influenced by skin microbiota.
17 citations
,
August 2020 in “Stem Cell Research & Therapy” This study found that a 3D co-culture of endothelial colony-forming cells and adipose-derived stem cells restored stem cell properties and improved healing in a mouse model of chronic injury.
17 citations
,
March 2016 in “PubMed” This review discusses the potential and limitations of adipose-derived stem cells and their conditioned medium for hair regeneration, highlighting novel preconditioning methods to enhance their effectiveness, without presenting new clinical results.
17 citations
,
July 2014 in “Expert Opinion on Biological Therapy” This study concluded that the new subfractionation culturing method generates highly homogeneous adipose-derived stem cells with enhanced mitogenic, paracrine, and hair growth-promoting effects compared to traditional isolation methods.
17 citations
,
November 2022 in “Biomedicine & Pharmacotherapy” This study reviewed recent developments in cell therapy for hair loss, finding adipose-derived stem cells and dermal sheath cup cells as promising alternatives to conventional treatments, albeit with varying effectiveness and challenges in trichogenecity and hair growth outcomes.
16 citations
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November 2020 in “PLOS ONE” This study found that lack of sleep, increased physical activity, and alopecia were associated with a higher risk of COVID-19 infection, while low-dose alcohol intake, hand hygiene, and daily fruit consumption were linked to reduced morbidity.
16 citations
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June 2019 in “Industrial Biotechnology” In this study, researchers found that the conventional solvent extraction method yielded the highest polyphenol content and antioxidant activity from Ascophyllum nodosum seaweed on Québec's North Shore.
16 citations
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December 1996 in “International Journal of Dermatology” This case report describes a 23-year-old man with scurvy, characterized by perifollicular hemorrhages, gum disease, and other symptoms due to a diet low in fresh fruits and vegetables.
16 citations
,
April 1985 in “Archives of dermatology” This review discusses various treatments for pityriasis rubra pilaris, including vitamin A, methotrexate, and systemic steroids, reporting historical anecdotal evidence without new clinical results.
14 citations
,
June 2021 in “Archives of Dermatological Research” In this study, researchers evaluated the use of adipocyte-derived stem cell conditioned media combined with fractional laser or microneedling for treating refractory alopecia areata, finding that 64.3% of patients had significant hair regrowth, suggesting this combination may be an effective and safe treatment option.
13 citations
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May 2025 in “Journal of Cosmetic Dermatology” This study reports that adipose mesenchymal stem cell-derived exosomes and platelet-rich plasma both improved the condition of photoaged facial skin, with no significant difference in effectiveness between the two treatments, potentially offering a quicker and less invasive option for patients.
13 citations
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March 2020 in “Acta veterinaria Scandinavica” This study found that wounds in dogs treated with allogeneic adipose-derived mesenchymal stem cells showed faster and improved healing compared to wounds receiving conventional treatment.