34 citations
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March 2009 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, l-Ascorbic acid 2-phosphate was found to stimulate hair follicle growth in vitro by promoting IGF-1 expression via the PI3K pathway.
33 citations
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January 2006 in “Journal of Dermatological Science” This article reviews the molecular interactions involved in hair follicle cycling and highlights the role of dermal papilla cells, but it presents no new research findings.
22 citations
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April 2006 in “Journal of Dermatological Science” This study reports that versican expression plays a crucial role in maintaining the anagen phase and hair inductive properties, as shown in a transgenic mouse model and hair growth assays.
20 citations
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January 1995 in “Journal of Dermatological Science” This study found that topical application of cyclosporin A and FK506 induces new hair growth in mice, while ascomycin and rapamycin do not, suggesting hair induction is not due to immunosuppression.
17 citations
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March 2021 in “Expert Opinion on Biological Therapy” This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.
15 citations
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June 2016 in “Computers in Biology and Medicine” This study's simulation found that Ascorbyl Tetraisopalmitate penetrates more efficiently through the skin's stratum corneum than via the infundibulum, following different pathways and dynamics in each membrane.
14 citations
,
November 2007 in “Journal of Dermatological Science” This review discusses the roles of epithelial-mesenchymal interactions and dermal papilla in hair follicle growth and cycling, but it reports no new clinical results.
14 citations
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December 2019 in “International Journal of Phytocosmetics and Natural Ingredients” This study found that a conditioner containing Spirulina platensis and Ascophyllum nodosum extracts improved hair shine and reduced combability force after 28 days of use.
13 citations
,
November 2010 in “Experimental Dermatology” This study found that L-ascorbic acid 2-phosphate could reduce DHT-induced DKK-1 expression in balding scalp cells, suggesting potential for treating androgen-driven hair loss.
4 citations
,
January 2025 in “Pharmaceutics” This study found that spanlastic gel loaded with thymoquinone and ascorbic acid improved skin deposition and tyrosinase inhibition, suggesting potential as a treatment for hyperpigmentation.
2 citations
,
March 2013 in “Phytotherapy Research” This study found that ascorbigen increased growth of dermal papilla cells but did not significantly protect against chemotherapy-induced alopecia in a mouse model, suggesting limited effectiveness for hair regrowth in this context.
1 citations
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June 2018 in “JAMA Dermatology” This abstract does not contain specific research findings or results, but instead provides information related to the JAMA Dermatology journal's online platform and services.
August 1994 in “Journal of dermatological science” Cyclosporin A and FK506 can start new hair growth in mice, but ascomycin and rapamycin cannot.
August 2021 in “Josai University Repository of Academia (Josai University)” This study found that Sol/ASC-DP nanoparticles could enhance the skin permeability of minoxidil due to improved stability and hydrophobic interactions in the nanoparticle structure.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” In this mouse study, the absence of the Ascl4 gene did not affect the development of hair follicles, teeth, or mammary glands, suggesting it is non-essential for these processes.
November 2023 in “Journal of Investigative Dermatology” This study found that Adipose Stem Cell-derived Exosomes may improve hair growth and scalp rejuvenation, with clinical evidence showing increased hair counts and improved hair thickness compared to minoxidil.
April 2023 in “Journal of Investigative Dermatology” This study found that adipose stem cell exosome treatment may improve hair growth and scalp rejuvenation, outperforming minoxidil and showing promise in clinical trials for hair loss, including androgenic alopecia.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, topical application of adipose stem cell exosomes was found to reduce facial redness in atopic dermatitis patients treated with dupilumab, while improving skin hydration and decreasing inflammation markers over 12 weeks.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported that adipose stem cell exosomes, combined with microneedling, improved facial skin wrinkles, elasticity, hydration, and pigmentation compared to a placebo, with significant results on the Global Aesthetic Improvement Scale and no serious adverse events noted in treated individuals.
November 2023 in “Journal of Investigative Dermatology” Adipose stem cell exosomes may effectively treat atopic dermatitis by reducing inflammation and improving skin health.
In this study, imaging techniques showed that nanostructured lipid carrier formulations distributed ascorbic acid more effectively across skin layers compared to conventional cream formulations, suggesting a better method for skin permeation.
September 2019 in “Journal of Investigative Dermatology” This study found that co-culturing dermal papilla cells in a 3D structure with adipose-derived stem cells may enhance the expression of hair inductivity markers compared to 2D cultures.
September 2018 in “Journal of Society of Cosmetic Chemists of Japan” This study found that applying a solution containing oil-soluble vitamin C to damaged hair improved hair cuticle condition and water repellency, suggesting a new cosmetic function beyond its known skin whitening effects.
June 2014 in “Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science” This study reports that using ascorbic acid or orlistat can significantly inhibit the metabolism of testosterone esters into malodorous metabolites by axillary bacteria, suggesting potential new deodorant applications.
This study found that encapsulating ascorbyl palmitate in curcumin-grafted nanoparticles increased its stability compared to unencapsulated forms, with primary skin penetration occurring through hair follicles in pig skin.
January 2011 in “Journal of Liaoning University of Traditional Chinese Medicine” This article reviews the Traditional Chinese Medicine approach to treating androgenetic alopecia and reports no clinical results, suggesting a conceptual imbalance of Yin and Yang as the underlying issue.
9 citations
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June 2022 in “Plants” This study found that shallot extract may promote hair growth in androgenetic alopecia by reducing inflammation and modulating gene expression related to key hair growth pathways.
8 citations
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November 2007 in “Skin Pharmacology and Physiology” In this study, skin stretching significantly increased the delivery of retinyl ascorbate into the dermis, while sealing hair follicles did not affect absorption through native skin.
7 citations
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August 2021 in “ChemEngineering” This study found that Soluplus and L-ascorbyl 2,6-dipalmitate nanoparticles may improve minoxidil's skin permeability through stable hydrophobic interactions, enhancing its potential for targeted skin application.