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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

Etoposide is effective in treating several cancers, especially small cell lung cancer, with acceptable side effects.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The patient's liver did not fully grow back and she had serious temporary side effects after a very large liver surgery.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Doctors need to be better prepared to assess and treat obesity in patients.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Reconstruct lips with proper planning, templates, and revisions for appearance and function.

Patients with Bohring-Opitz syndrome and ASXL1 mutations need regular kidney ultrasounds to check for tumors.