32 citations
,
December 2013 in “Biological & Pharmaceutical Bulletin” In this study, rice bran supercritical CO2 extract demonstrated potential to promote hair growth in mice, increasing hair follicles and growth factor expression, similarly to 3% minoxidil.
32 citations
,
June 2012 in “PLoS ONE” This study found that locally injected zalutumumab in healthy volunteers induced a papulopustular rash similar to systemic EGFR inhibitors, and that IL-8 inhibition reduced this dermatological side effect.
31 citations
,
April 2018 in “Royal Society open science” This study found that mange-infected bare-nosed wombats have increased heat loss, higher metabolic rates, altered behavior, and disrupted fatty acid composition compared to healthy individuals.
31 citations
,
October 2010 in “Progress in lipid research” This review discusses the role of LPA(3) in embryo implantation and its genetic connection with prostaglandin signaling, but reports no new clinical results.
31 citations
,
September 2009 in “Natural Product Research” In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.
30 citations
,
July 2018 in “Scientific Reports” In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.
30 citations
,
October 2015 in “Journal of Ethnopharmacology” This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.
30 citations
,
January 2013 in “Obesity Surgery” This review summarizes the effects and complications of bariatric surgery on skin, noting it can alter existing skin conditions like psoriasis and trigger new dermatoses, but provides no new clinical results.
29 citations
,
June 2018 in “Scientific Reports” In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.
29 citations
,
July 2014 in “PloS one” In this study, Meis1 was found to regulate epidermal homeostasis and act as a proto-oncogenic factor in skin tissues, with differences in expression patterns between normal and tumor cells.
29 citations
,
June 2014 in “Drug delivery” This study reported that nanoemulsions significantly improved the skin permeability of thiocolchicoside compared to its aqueous solution, suggesting they are effective carriers for its transdermal delivery.
28 citations
,
September 2013 in “Expert Opinion on Therapeutic Patents” This review discusses various resveratrol derivative patents for therapeutic, nutraceutical, and cosmetic use, but reports no clinical results and notes that claims of improved efficacy lack trial evidence.
28 citations
,
September 2008 in “Current Pharmaceutical Design” This review discusses hypersensitivity reactions to anticoagulants like ASA and heparins, highlighting their rare but potentially life-threatening nature, and emphasizes the need for meticulous allergy testing to find safe alternatives.
27 citations
,
June 2013 in “Genes & development” This study found that L-type channel blockers can induce hair growth in Timothy syndrome by overcoming delays in anagen phase, suggesting a potential therapeutic role for tissue regeneration.
27 citations
,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified somatostatin as a potential secretory factor contributing to the immune privilege of human hair follicles.
27 citations
,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified 12 new genes associated with the hair follicle and various stages of the hair cycle in mice, which could lead to novel targets for hair growth or depilation therapies.
27 citations
,
September 2000 in “JAMA” The document suggests changing medical education to balance generalists and specialists, focusing on patient needs.
26 citations
,
May 2021 in “International Journal of Molecular Sciences” In this review, researchers examined the physiological benefits of Cheonggukjang, a salt-free fermented soybean paste, highlighting its various health-promoting components that may contribute to improved heart health, diabetes management, and cancer prevention, among other benefits.
26 citations
,
April 2019 in “Genes” In this study, researchers identified novel long non-coding RNAs related to cashmere fineness in goats, highlighting a potential regulatory network involving lncRNA XLOC_008679 and its target gene KRT35.
26 citations
,
December 2017 in “Journal of Investigative Dermatology” This study found that the acceleration of endothelial to mesenchymal transition due to loss of Notch signaling led to delayed wound healing and increased scarring in skin wounds.
26 citations
,
October 2012 in “Dermatologic Clinics” This article reviews recent advancements in hair transplantation techniques, particularly follicular unit transplantation, and suggests an expansion of its applications beyond male pattern hair loss, but reports no new results.
25 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.
25 citations
,
March 2017 in “Experimental Dermatology” This review discusses various aspects of hair follicle biology and highlights unresolved questions and potential new research avenues, but presents no new experimental findings.
25 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that applying topical imiquimod during mid and late telogen in mice activates hair follicle stem cells and influences immune cell infiltration, promoting hair cycle entry independently of Wnt signaling.
25 citations
,
November 2014 in “British Journal of Dermatology” This study found various ABC transporters are transcribed in human hair follicles, suggesting their possible role in HF biology and potential for new therapeutic interventions.
25 citations
,
September 2014 in “Biological Research” This study found that arctiin, a compound from Arctium lappa, demonstrated protective effects against oxidative stress-induced dysfunction in human hair dermal papilla cells, suggesting potential therapeutic use for alopecia.
25 citations
,
July 2013 in “Actas Dermo-Sifiliográficas” This review discusses consensus guidelines for the use of acitretin in psoriasis, highlighting its ongoing utility in both mono and combination therapies, despite not always being recognized in treatment guidelines.
25 citations
,
February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.
25 citations
,
January 2002 in “Folia Pharmacologica Japonica” This article reviews the proposed mechanism of minoxidil in treating androgenetic alopecia, suggesting it may prolong the anagen phase by modulating cell growth factors and vascular activity, but reports no new results.
24 citations
,
December 2018 in “Life sciences” This review discusses the role of lysophosphatidic acid in skin physiology and pathology, highlighting its significance in processes like wound healing and hair follicle development, but reports no new clinical findings.