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The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Androgens may block hair growth signals, targeting this could treat hair loss.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Biomaterials combined with stem cells show promise for improving tissue repair and medical treatments.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

The treatment was ineffective in humans.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Cromolyn sodium's effectiveness for treating asthma in children under 2 is unclear, possibly more beneficial for older children, and further research is needed.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

RTA 408 cream protects mice from radiation skin damage.