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Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Trichohyalin is also found in the outer layers of normal human skin.

Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.

Feed restriction in sheep leads to finer wool fibers but may reduce wool quality.

The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.

Mice without the Sp6 gene have problems developing several body parts, including hair, teeth, limbs, and lungs.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Ketoconazole shampoo with finasteride improves hair density in men with hair loss.

A certain genetic variant in the androgen receptor may predict the severity of COVID-19 in men.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

COVID-19 may harm male fertility and damage the reproductive system.

Grouping certain skin cells together activates a growth pathway that helps create new hair follicles.

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

Hormones and genes affect hair growth and male baldness.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.