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Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

ERG increases SOX9, promoting prostate cancer growth and invasion.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Pumpkin seed products may help improve prostate and bladder health by blocking certain enzymes and hormone receptors.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

A new compound effectively inhibits human 5α-reductase 1.

Testosterone is crucial for development, growth, and various body functions in mammals.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Androgens slow hair growth by altering Wnt signaling in balding cells.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.