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A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

New therapies are being developed that target integrin pathways to treat various diseases.

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Tadalafil and Finasteride may help treat aggressive melanoma.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Inhaling medicine may reduce side effects and improve treatment for a major lung cancer type.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

Finasteride may improve prostate cancer treatment outcomes.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

Testosterone may slow down wound healing and increase inflammation.

Mutations in the enzyme don't significantly change how it binds to its specific substances.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.