September 2023 in “Animals” Genes linked to wool fineness in sheep have been identified.
January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology” Minoxidil increases cell layer permeability by reducing tight junction proteins and raising ROS levels.
September 2017 in “Asian Journal of Beauty and Cosmetology” The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.
21 citations
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March 2019 in “Critical Reviews in Clinical Laboratory Sciences” The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.
25 citations
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November 2016 in “Progress in Biophysics & Molecular Biology” R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.
21 citations
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April 2016 in “Reproductive Biomedicine Online” The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.
11 citations
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January 2017 in “Biochemical and biophysical research communications” 1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.
688 citations
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June 2007 in “Cell Stem Cell” Removing the ATR gene in adult mice causes rapid aging and stem cell loss.
14 citations
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May 2018 in “Psychoneuroendocrinology” Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.
81 citations
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January 2003 in “The FASEB Journal” Follistatin helps hair growth and cycling, while activin prevents it.
11 citations
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November 1998 in “Journal of dermatological science” Knocking out certain genes in mice helps understand skin and hair growth problems.
13 citations
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August 2012 in “Pigment Cell & Melanoma Research” A mutation in the Adam10 gene causes freckle-like spots on Hairless mice.
January 2024 in “Journal of lipid research” Finasteride may lower cholesterol and slow heart disease progression.
Whale oil significantly promotes hair growth and may be a safe, effective alternative to minoxidil.
236 citations
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
68 citations
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December 2018 in “Trends in Cell Biology” Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.
January 2006 in “Advances in developmental biology” The Hairless gene is crucial for healthy skin and hair growth.
5 citations
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September 2019 in “iScience” Deleting the Trf1 protein in mice is safe and may help prevent cancer without major side effects.
1 citations
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January 2024 in “Nature communications” Activating TLR5 in the gut can extend lifespan and improve health in aged mice.
188 citations
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June 1998 in “Molecular cell” Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.
18 citations
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June 2017 in “Proceedings of the National Academy of Sciences of the United States of America” A gene called Gk5 controls lipid production in the skin and affects hair growth.
13 citations
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May 2019 in “iScience” EGFR helps control how hair grows and forms without needing p53 protein.
12 citations
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March 2016 in “Biochemical and Biophysical Research Communications” Sulforaphane may help with hair growth by breaking down a hormone that causes hair loss.
77 citations
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March 2021 in “Nature” Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.
65 citations
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June 2003 in “EMBO journal” Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
53 citations
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May 2021 in “Cell Host & Microbe” Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.
5 citations
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July 2018 in “Journal of Dermatological Science” Adjusting estradiol-ANGPT2 levels can promote hair growth in female pattern hair loss.
23 citations
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June 2019 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.