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Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

Semecarpus anacardium leaf extracts may offer safe, effective cancer treatment alternatives.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

Five-alpha reductase inhibitors, like finasteride and dutasteride, can treat enlarged prostates, improve urination, reduce need for prostate surgery, and lower the risk of prostate cancer, but may increase the risk of higher grade prostate cancer. They can also treat male pattern baldness.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Some treatments for autoimmune hair loss work, but JAK inhibitors like tofacitinib are promising for regrowth.

5α-reductase inhibitors like finasteride and dutasteride can help treat skin disorders stimulated by androgens, such as hair loss and acne.

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

Applying certain inhibitors to the skin can promote hair growth without harming cells.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

5-alpha reductase inhibitors, like finasteride and dutasteride, are used for prostate issues, hair loss, and excessive hair growth, may help with COVID-19, but can cause sexual and mental health side effects, and their use in preventing prostate cancer needs more examination.

5α-Reductase inhibitors may increase depression risk but not dementia or suicide.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

Alpha-blockers and 5-alpha reductase inhibitors are main treatments for BPH, with new support for phosphodiesterase-5 inhibitors and beta-3 agonists.