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The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Flutamide caused damage to male rat reproductive organs and may affect fertility.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Skin cancer often starts from Lgr5+ progenitor cells.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Parthenolide promotes hair growth in mice and may influence pathways related to male pattern baldness.

Sex hormones affect brain injury differently in males and females.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

New compounds may help treat prostate cancer by reducing cell growth.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The conclusion is that future hair loss treatments should target the root causes of hair thinning, not just promote hair growth.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Lasers, microneedling, and PRP improve skin rejuvenation and repair, with PRP enhancing the effects when combined with other treatments.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

The STIM1 R304W mutation in mice leads to bone changes and teeth hair growth.

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.