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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Analog 23 is a promising compound for prostate cancer treatment.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

Mutations in certain receptors can cause diseases and offer new treatment options.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Finasteride may improve prostate cancer treatment outcomes.

We need better ways to test and understand SARMs to make safer and more effective treatments.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

Androgens can help prevent memory problems caused by apoE4.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Mice with human gene experienced hair loss when treated with DHT.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

Scutellaria baicalensis extract and baicalin may help prevent hair loss.