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This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.

This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.

This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.

In this laboratory study, researchers reported that Camellia sinensis seed flavonoids significantly reduced oxidative stress and inflammation in UV-irradiated skin cells by modulating key signaling pathways, highlighting its potential as a skincare ingredient for anti-inflammatory and anti-photoaging benefits.

This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.

In this study, maternal melatonin implantation in pregnant rabbits reduced hair follicle cell apoptosis and increased hair follicle density in their neonatal offspring, suggesting a beneficial impact on hair follicle development mediated through specific molecular pathways.

This study found that in pregnant rats, the suppression of ACTH responses to IL-1β is linked to the action of endogenous opioids and AP, with AP potentially inducing opioid inhibition through increased pENK-A expression.

This study reported that the IL1A 4-bp indel polymorphism is associated with a reduced risk of alopecia areata in Chinese populations, possibly through miR-122 mediated regulation of IL-1α expression.

This review explores the potential role of caveolin-1 in cicatricial alopecia, particularly frontal fibrosing alopecia, and discusses possibilities for targeted therapies without providing new research results.

In this study, short-term liraglutide treatment led to significant weight loss in obese women with newly diagnosed PCOS and a higher metabolic risk profile compared to metformin.

This phase 1 study reported that after administering supratherapeutic doses of cortexolone 17α‐propionate, a topical antiandrogen intended for hair loss treatment, there was no effect on the QTc interval, indicating no measurable cardiac safety concerns in the concentration range tested.

This study suggests that elevated levels of IL-17A and IL-23 in alopecia areata may play roles in disease severity and activity, providing insights into potential therapeutic targets.

This study found that inhibiting AP1 transcription factor activity in the suprabasal epidermis of mice alters keratinocyte gene expression, reducing barrier integrity and mimicking human keratoderma.

This study found that combining fractional erbium-glass laser therapy with topical minoxidil significantly improved hair density and diameter in men with androgenetic alopecia compared to using minoxidil alone over a 24-week period, with no serious adverse events reported.

In this study, ritlecitinib was generally well tolerated in pediatric alopecia areata patients aged 6 to <12 years, with no severe or serious adverse events reported, and the drug's pharmacokinetic parameters were successfully characterized.

In this study, topical application of Cyclosporin A on mice skin induced hair growth by transitioning follicles from telogen to anagen, but no effect was observed on cultured human hair follicles.

In this study, Ageratum houstonianum ethanolic extract and its active component agerarin were found to promote hair growth and follicle elongation by increasing SCUBE3 expression via activation of MAPK–AP-1 signaling in human dermal papilla cells, suggesting potential therapeutic value for treating hair loss.

This study found that Gynostemma pentaphyllum hydrodistillate and Damulin B exert significant anti-photoaging effects in UVB-irradiated models by reducing oxidative stress, improving ECM integrity, and enhancing skin hydration and elasticity.

This study reported that using plain bottles instead of commercial kits for extracting platelet-rich plasma may be an effective method for treating hair loss.

In this study, the CYP 21A2 gene p.V281L mutation was associated with an increased susceptibility to familial frontal fibrosing alopecia, suggesting an antigen-driven mechanism linked to certain human leukocyte antigen haplotypes.

In this study, dermoscopic examination of COVID-19 patients revealed significant microvascular changes in the proximal nailfold, such as avascular areas and disorganized capillary architecture, compared to healthy controls, with some regression of these changes observed over time.

This study found that patients with autoimmune skin diseases showed a statistically significant occurrence of hearing disabilities, suggesting the need for audiological evaluations in these patients.

This study found that the majority of COVID-19 survivors experienced post-discharge symptoms, with fatigue being the most common, and these symptoms significantly affected quality of life, especially in relation to the severity of their initial infection.

This review discusses the complex interplay of genetic and environmental factors in Type 1 Diabetes Mellitus and its frequent association with other autoimmune conditions, focusing on personalized medicine to potentially improve patient care.

This retrospective study concluded that alopecia areata in elderly patients showed mild severity and a favorable treatment response, with no link found between hair graying and the extent of hair loss.

This study found no significant association between the MMP-1 gene polymorphisms rs1799750 and androgenetic alopecia in the sample population.

In this study, post-COVID-19 patients showed substantial multisystem symptoms six to eight months after infection compared to controls, with a higher burden in non-respiratory areas like fatigue and neurocognitive issues, despite respiratory symptoms largely resolving.

This study highlighted the potential of iron chelators, deferoxamine and deferiprone, to improve hair density, thickness, and elasticity and reduce hair loss by up to 66.8% over six months in individuals with autoimmune alopecia, suggesting they may offer a promising therapeutic option.

This study in a California safety net hospital found no apparent increase in alopecia areata incidence among individuals who received COVID-19 vaccination compared to those unvaccinated, with odds ratios indicating a lower risk in the vaccinated group.

This review summarizes 25 small molecule drugs with in vitro and in vivo data for COVID-19 treatment, highlighting their structural diversity and potential to guide future antiviral discovery.