October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.
29 citations
,
March 2019 in “British Journal of Dermatology” Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
290 citations
,
December 2017 in “Journal of The American Academy of Dermatology” This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.
236 citations
,
July 2001 in “Trends in Molecular Medicine” This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
4 citations
,
May 2019 in “Journal of The European Academy of Dermatology and Venereology” Hair loss treatment caused more hair loss in a man.
February 2026 in “Frontiers in Medical Technology” This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.
April 2022 in “Research Square (Research Square)” This study established the R-7 dermal papilla cell line, which retained essential characteristics of primary cells without undergoing malignant transformation, suggesting its potential for future hair research.
September 2014 in “Aktuelle Dermatologie” This symposium review highlights past, present, and future developments in skin research, celebrating the work of Prof. Johanna Brandner and Dr. Peter Arne Gerber, without reporting new clinical results.
26 citations
,
July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.
11 citations
,
June 2022 in “Frontiers in immunology” This review discusses the challenges in identifying specific hair follicle antigens involved in initiating alopecia areata and highlights the need for further research to understand its etiopathogenesis, reporting no new results.
9 citations
,
November 2018 in “Acta Clinica Belgica” This case report suggests that spironolactone may induce prostate cancer proliferation in patients on abiraterone acetate, advising against its use for managing treatment-associated side effects in these individuals.
8 citations
,
May 2021 in “Bioengineering & translational medicine” This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.
July 2026 in “Organoid Research” In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.
14 citations
,
June 2015 in “Toxicology and Industrial Health” This study found that low doses of bisphenol A may increase proliferation of the ventral prostate in adult rats by altering the estrogen to androgen ratio and gene expression.
October 2023 in “Frontiers in medicine” This study analyzed screening data from 218 alopecia areata patients before starting Janus kinase inhibitors, revealing the importance of pre-treatment screening due to risks of infections like tuberculosis and hepatitis B, with 74.8% of patients proceeding to treatment in real-world settings.
49 citations
,
April 2000 in “Journal of The American Academy of Dermatology” This article discusses the etiology, clinical features, diagnosis, histopathology, and treatment of alopecia areata but reports no new clinical findings; it emphasizes the palliative nature of current treatments.
4 citations
,
April 2010 in “Expert review of dermatology” This article discusses the immune privilege in hair follicles and suggests that restoring its collapse might be an effective strategy for treating alopecia areata and cicatricial alopecia, but it reports no new clinical results.
23 citations
,
January 2016 in “Frontiers in immunology” This review discusses the potential of combining low-dose IL-2 with islet antigens to enhance antigen-specific Treg function in type 1 diabetes, but reports no new clinical results.
November 2025 in “Advanced Healthcare Materials” This review explores advancements in bioprinting technologies for developing in vitro skin models that replicate immune-mediated skin diseases, highlighting their potential to reduce animal testing and enhance research and product testing capabilities in dermatology.
September 2025 in “JID Innovations” This study suggests that macrophages, particularly CD206+ macrophages, play a crucial role in squaric acid dibutylester-induced hair growth in alopecia areata treatment.
32 citations
,
August 2024 in “Journal of Investigative Dermatology” In vitro skin models are improving but still need more innovation to fully replicate human skin.
81 citations
,
February 2016 in “Veterinary pathology” This review discusses the commonly observed pathological findings in progeroid mouse models and highlights the importance of understanding mouse strain backgrounds and progeria-related phenotypes for accurate pathology data interpretation.
August 2024 in “Current Protocols” In this study, researchers described protocols using C3H/HeJ mice to reliably induce alopecia areata through full-thickness skin grafts or adoptive transfer of cultured lymphoid cells, offering valuable models for studying the disease and testing new drug therapies.
119 citations
,
December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.
24 citations
,
October 2022 in “Cell Regeneration” This study describes a new mouse model for vitiligo that mimics key clinical features such as skin depigmentation and CD8 + T cell infiltration, providing a useful tool for in-depth research and drug discovery.
9 citations
,
September 2009 in “PubMed” This case report presents the first evidence of significant antigen presenting cells around hair follicles in a patient with alopecia due to active systemic lupus erythematosus.
February 2026 in “Nature Communications” In this study, researchers created a detailed human skin cell atlas by analyzing over 700,000 cells, finding that disrupted communication among specific immune and stromal cell subsets may play a key role in initiating and sustaining chronic skin inflammation in atopic dermatitis.
8 citations
,
March 2022 in “Cancers” This study found that proton minibeam radiotherapy demonstrated a potential tissue-sparing effect in epidermis models by spatially confining DNA damage, suggesting reduced side effects in radiotherapy.
5 citations
,
October 2020 in “Bioengineering & translational medicine” This study demonstrates the use of microscopy-guided laser ablation to create a highly structured 3D hydrogel-based organotypic skin model with folliculoid structures, potentially useful for studying hair follicle development or bioactive substance screening.