27 citations
,
July 2008 in “The Journal of Steroid Biochemistry and Molecular Biology” The new compounds may be more effective and cheaper than current treatments for conditions like baldness.
88 citations
,
June 2016 in “Human Reproduction Update” This review discusses developments in oral contraceptives, highlighting improved individualization, reduced side effects, and enhanced suitability for various women's health needs, but it reports no new clinical results.
38 citations
,
July 2012 in “international journal of endocrinology and metabolism” This review discusses the clinical use of anti-androgen medications and highlights emerging evidence supporting plant-derived anti-androgens like spearmint tea for managing PCOS, but reports no new clinical results.
36 citations
,
July 1980 in “Journal of Toxicology and Environmental Health” In this animal study, rats given high doses of ethynylestradiol showed dose-related estrogenic effects, delayed tumor onset in females, and no overall increase in tumor incidence compared to controls.
4 citations
,
July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” In this study, hirsute women treated with cyproterone acetate and ethinyloestradiol experienced significant reductions in sebum secretion and hair growth after several months.
12 citations
,
April 1995 in “Journal of Medicinal Chemistry” In this study, 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides were synthesized and evaluated in vitro as potential 5 alpha-reductase inhibitors and antiandrogens.
187 citations
,
December 2005 in “Experimental Dermatology” This article discusses the role of estrogens in skin aging and reports no new findings; it highlights the potential of selective ER modulators to improve skin health without systemic side effects.
51 citations
,
February 2010 in “Analytical and Bioanalytical Chemistry” Researchers developed a method to detect hormone-blocking drugs in wastewater and found them in Beijing's sewage, suggesting they can survive sewage treatment.
48 citations
,
September 2013 in “Oncologist” This study reported that alopecia is a common but often underreported side effect of endocrine-based cancer therapies, with tamoxifen showing the highest incidence of hair loss among analyzed treatments.
39 citations
,
March 2007 in “Journal of Cosmetic Dermatology” This study in identical twin males with androgenetic alopecia found that dutasteride significantly improved hair growth compared to placebo over one year.
24 citations
,
November 2009 in “Pharmaceutical Development and Technology” This study found that Transcutol P significantly enhanced the skin penetration of Finasteride in vitro, while cationic and anionic surfactants did not show such effects.
10 citations
,
December 2017 in “Chemosphere” In this study, BPA rapidly increased dendritic spine and synapse densities in cultured rat hippocampal neurons, with involvement of estrogen receptors and ERK1/2 and p38 pathways, but disrupted dihydrotestosterone's effects on synaptic plasticity.
8 citations
,
January 1987 in “Gynecological Endocrinology” This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.
6 citations
,
October 2012 in “Pediatrics” This case report describes an 11-year-old girl who experienced hot flashes and menarche after taking a Serenoa repens supplement for telogen effluvium, suggesting a possible but uncertain link between the supplement and hormonal changes.
3 citations
,
February 2021 in “Molecules” In this study, researchers developed a sensitive assay to measure the inhibition of steroid 5-α reductase (5AR) by chemicals like finasteride and dutasteride, revealing species-specific differences in inhibitor efficacy between human and fish cell lines.
3 citations
,
July 2014 in “Indian Journal of Surgery” Sex hormones might influence bladder cancer development, and aromatase inhibitors could increase risk in postmenopausal women.
1 citations
,
May 2025 in “International Journal of Advanced Biochemistry Research” This review discusses the phytochemical, pharmacological, and medicinal properties of Hibiscus rosa sinensis Linn. and reports no new clinical findings.
1 citations
,
December 2015 in “Endocrinology” This study suggests that dietary decanoic acid may manage hyperandrogenism and insulin resistance in PCOS, as observed in animal and cell model experiments.
This study identified that transgender patients face barriers in accessing oral healthcare, including discrimination and harassment, leading to increased stress, poorer oral health, and a diminished quality of life related to oral health.
Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.
This study formulated and evaluated a Hibiscus rosa-sinensis herbal gel, identifying a 20% concentration as superior in physical properties, suggesting its potential as an alternative drug delivery system.
February 1999 in “Drugs in R & D” The document concludes that various drugs for men's health issues are in development, with treatments for sexual dysfunction and prostate conditions being the most advanced.
January 2019 in “ISGE series” This study found that estradiol and other sex steroids reduced the capture of monocytes by human endothelial cells in vitro, potentially inhibiting the formation of atherosclerosis by promoting nCAM polysialylation, which interferes with leukocyte tethering to the vascular endothelium.
48 citations
,
February 1999 in “PubMed” This study found that the anticonvulsant effects of progesterone against PTZ-induced seizures in mice require conversion to allopregnanolone, as shown by the reversal of these effects with a 5alpha-reductase inhibitor.
October 2025 in “Frontiers in Toxicology” This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.
1 citations
,
November 2024 in “Archives of Dermatological Research” 44 citations
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December 2005 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that testosterone is converted to estrogenic steroids in vitro without aromatase involvement, suggesting that combining 5α-reductase and aromatase inhibitors might reduce estrogenic steroids more completely in vivo.
November 2020 in “Elsevier eBooks” This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.
6 citations
,
October 1993 in “Endocrinology” In this study, researchers found that finasteride inhibits progesterone synthesis by blocking cholesterol side-chain cleavage in mouse-derived MA-10 Leydig cells, but this effect may not be evident in human or rat cells.
July 2008 in “International journal of psychophysiology” This retrospective study found that cyproterone acetate, both alone and with estrogens, was safe, well tolerated, and induced modest feminizing effects in late-pubertal transgender female adolescents.