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The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Oxidative stress contributes to hair graying and loss as we age.

Fat cells in the skin help start healing and form important repair cells after injury.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

SHBG may be a useful early indicator and treatment target for PCOS.

Testosterone may slow down wound healing and increase inflammation.