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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The Rotterdam Study aims to understand various diseases in older adults.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Estrogen therapy can reduce skin aging but has cancer risks.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

New topical antifungals and delivery systems are improving treatment for fungal skin infections, but patient education and prevention are key.

Liposomes could improve how skin care products work but are costly and not very stable.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.