64 citations,
March 2006 in “Food Chemistry” The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.
51 citations,
January 2001 in “Biological & Pharmaceutical Bulletin” The bark of Myrica rubra contains compounds that can block testosterone effects and might help prevent hair loss.
44 citations,
March 2012 in “Fitoterapia” Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.
38 citations,
September 2006 in “Journal of Dermatological Science” Ketoconazole lotion can improve hair regrowth for some people with androgenetic alopecia.
38 citations,
January 2002 in “Biological & Pharmaceutical Bulletin” Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
36 citations,
July 2020 in “Frontiers in Medicine” Spironolactone might help protect against severe lung problems in COVID-19 patients.
19 citations,
June 1999 in “Steroids” Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.
16 citations,
July 2002 in “JOGC/Journal of obstetrics and gynaecology Canada” Birth control pills can help reduce mild to moderate acne in women.
12 citations,
March 2017 in “Medicinal Chemistry Research” Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.
7 citations,
July 2019 in “Scientific Reports” Finasteride helps reduce heart enlargement in heart failure patients.
3 citations,
September 2016 in “Natural Product Communications” Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.
1 citations,
April 2024 in “Journal of Pharmaceutical and Pharmacological Sciences” The mouse models are effective for testing new hair loss treatments.
1 citations,
January 2022 in “Food & Function” Certain Egyptian Sabal fruit extracts may help treat anti-androgenic diseases like benign prostatic hyperplasia.
November 2018 in “Journal of Molecular and Cellular Cardiology” Finasteride improves heart function and repairs damage after heart attack in mice.
November 2023 in “PubMed” Combining stem cell-conditioned media with anti-androgen drugs can improve hair growth in male pattern baldness.
59 citations,
May 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
7 citations,
June 2020 in “Translational Andrology and Urology” Finasteride for hair loss may cause lasting sexual, genitourinary, mental, and anti-androgenic side effects in young men.
6 citations,
December 2020 in “Dermatological reviews” COVID-19 may worsen with androgens; anti-androgen drugs could help.
7 citations,
January 2022 in “Plants” Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.
90 citations,
July 2009 in “PTR. Phytotherapy research/Phytotherapy research” Spearmint tea may reduce testosterone and self-reported hair growth in women with PCOS.
20 citations,
December 1997 in “Clinical Endocrinology” Spironolactone may help reduce hair loss in androgenic alopecia.
6 citations,
December 2022 in “International Journal of Molecular Sciences” Hormone imbalance is linked to Hidradenitis Suppurativa, a skin condition, and treatments like anti-androgenic therapy and metformin can help. It's also suggested to check patients for insulin resistance and Polycystic Ovary Syndrome.
1 citations,
January 2023 in “PubMed” Urtica dioica extract may help treat androgenic skin diseases by reducing a specific gene's activity.
1 citations,
December 2019 in “Dermatologic Therapy” Only anti-androgenic drugs likely halt AGA progression.
April 2022 in “Brazilian Medical Students” People with androgenetic alopecia may have a higher risk of severe COVID-19.
January 2020 in “The Journal of Sexual Medicine” Using 5α-reductase inhibitors for hair loss can cause lasting sexual, physical, mental, and vascular health issues in men, even after stopping the medication.
January 2014 in “Journal of Pharmaceutical Negative Results” Liquorice and Indian jujube root extracts don't help in fighting male pattern baldness.
January 2008 in “Dermatology Online Journal” Hormonal therapy like cyproterone acetate and spironolactone may help female hair loss, but more research is needed, especially for pre-menopausal women.
2 citations,
June 2022 in “Molecules” Connarus semidecandrus Jack extract promotes hair growth and thickness, reduces prostate cancer cell growth, and could potentially be used as a treatment for hair loss.
16 citations,
September 1964 in “The journal of investigative dermatology/Journal of investigative dermatology” New compounds can block testosterone effects in rats and might help treat conditions like prostate cancer and acne.