65 citations
,
February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.
27 citations
,
June 2017 in “Expert opinion on investigational drugs” This review discusses ongoing and past trials for novel acne treatments, focusing on topical agents with potential sebosuppressive, antimicrobial, or anti-inflammatory effects, without reporting new clinical results.
16 citations
,
July 2002 in “JOGC/Journal of obstetrics and gynaecology Canada” This review discusses treatments for female acne, highlighting the effectiveness of low-dose oral contraceptives and noting their similar side effects to placebo; it reports no new clinical results.
6 citations
,
November 1993 in “Contact dermatitis” Spironolactone in anti-acne cream can cause allergic skin reactions in some people.
September 2017 in “Zenodo (CERN European Organization for Nuclear Research)” This study suggests that a topical hydroalcoholic extract of liquorice root significantly reduced sebaceous gland size in Syrian hamsters, indicating potential for use in anti-acne therapy.
January 2014 in “Journal of Changchun University of Traditional Chinese Medicine” This study found that resolving acne capsules may suppress acne keratosis and regulate hormone levels in a rabbit ear acne model, showing potential anti-acne effects.
January 2011 in “The Chinese Journal of Dermatovenereology” This study found that curcuma anti-acne gel reduced comedo formation and improved skin characteristics in a rabbit ear acne model, showing potential for treating acne.
April 2024 in “Molecules/Molecules online/Molecules annual” This review discusses the potential of P. polyphylla saponins to treat acne through antibacterial, anti-inflammatory, immunomodulatory, and antioxidant effects, noting that acne's complex pathogenesis makes this line of research promising for future studies.
4 citations
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December 2022 in “Evidence-based Complementary and Alternative Medicine” This study found that phenolic compounds from Quercus acutissima, particularly casuarinin, showed strong antioxidative, anti-inflammatory, and antiacne effects in mouse macrophage cells, suggesting potential therapeutic candidates for acne.
4 citations
,
April 2016 in “Journal of Dermatology Research and Therapy” This article discusses the multifactorial nature of acne vulgaris, detailing its link to androgen-induced sebum production, altered keratinisation, inflammation, and bacterial colonisation, but reports no new research findings.
88 citations
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July 2001 in “British journal of dermatology/British journal of dermatology, Supplement” This study reported that antimicrobial and topical retinoid therapies led to significant changes in the lipid profiles of sebaceous follicular infundibulum, with increased triglycerides and ceramide subfractions observed.
June 2024 in “JURNAL BIOLOGI TROPIS” In this systematic literature review, researchers reported that Moringa oleifera Lamk. leaf extract may serve as a potential anti-acne agent, demonstrated by its ability to inhibit the growth of acne-causing bacteria in laboratory settings.
July 2005 in “SKINmed/Skinmed” This study reported that BRL 7660 significantly reduced sebum secretion and acne symptoms in human studies with topical administration, but the placebo effect and commercial pressures halted further investigations.
19 citations
,
January 2022 in “Journal of Nanomaterials” This study concluded that an adapalene nanohydrogel containing Tween-80 could be a promising and stable topical treatment option for acne vulgaris due to enhanced skin permeability and stability compared to other formulations.
September 2020 in “Journal of Education, Health and Sport” In this study, common side effects of isotretinoin, including dry lips, mucous membrane dryness, tiredness, and mood changes, were frequently reported among Polish patients, though their severity was usually mild.
50 citations
,
November 2015 in “Journal of pharmacological sciences” This study found that applying α-mangostin-loaded nanoparticles significantly improved acne vulgaris in patients, with no notable skin irritation reported in human volunteers.
15 citations
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April 2022 in “Biointerface Research in Applied Chemistry” This review presents current evidence on medicinal plants and their phytoconstituents, such as phenolic compounds, used in acne treatment, highlighting their potential as alternatives to conventional therapies due to issues like antibiotic resistance and high cost.
7 citations
,
October 2018 in “South African journal of botany” This study found that the plant Clausena anisata exhibited promising antimicrobial, antioxidant, and anti-inflammatory activities against acne-causing bacteria and inflammation, suggesting its potential as a candidate for further anti-acne treatment research.
2 citations
,
May 2023 in “Experimental dermatology” In this study, researchers used advanced four-dimensional optical imaging techniques to observe changes in skin afflicted with acne, finding increased epidermal thickness, keratinized hair follicles, inflammation, and aggregated blood flow, helping to distinguish between inflammation and reparative phases of acne progression.
1 citations
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May 2018 in “International Journal of Advanced Community Medicine” In this research, a new cream containing salicylic acid was developed to treat acne vulgaris, showing no allergic reactions or skin irritation and maintaining stability in controlled conditions, suggesting potential future benefits for skin care and anti-acne treatment.
June 2026 in “International Journal of Drug Delivery Technology” This study developed a Hyaluronic acid-Carbopol liposomal gel co-loaded with Adapalene and Clindamycin Phosphate, optimized to improve skin penetration and anti-acne efficacy, showing enhanced drug delivery, superior clinical effectiveness, and excellent skin tolerability compared to commercial formulations.
August 2021 in “Research Square (Research Square)” This study found that BEO inhibited cell proliferation and inflammatory mediator release in a human keratinocyte acne model and reduced acne lesion severity in a rabbit model, suggesting its potential as a natural alternative to conventional acne treatments.
January 2018 in “Springer eBooks” The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.
May 2024 in “Aktualʹnì problemi sučasnoï medicini: Vìsnik Ukraïnsʹkoï medičnoï stomatologìčnoï akademì” This review discusses the multifactorial pathogenesis of acne and current treatment strategies including the use of isotretinoin and spironolactone, but reports no new clinical results.
175 citations
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April 1982 in “Journal of The American Academy of Dermatology” This study found that oral isotretinoin achieved good to excellent clinical results in treating severe inflammatory acne, severe rosacea, and gram-negative folliculitis.
88 citations
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January 2001 in “Dermatology” This study found that the monophasic oral contraceptive ethinylestradiol/chlormadinone acetate was more effective in treating mild to moderate papulopustular acne in women than ethinylestradiol/levonorgestrel.
13 citations
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March 2014 in “Cutaneous and Ocular Toxicology” This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
8 citations
,
July 2018 in “European Journal of Dermatology” A medication may help with hair growth in psoriasis, and a skin condition might be linked to a specific bacteria.
5 citations
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January 2018 in “Springer eBooks” Acne in dark skin is influenced by environmental factors and can lead to hyperpigmentation, with various treatment options available.
3 citations
,
January 2016 in “Annals of Dermatology” This article discusses the multifactorial nature of acne, including its association with follicular hyperkeratosis, sebaceous lipids, Propionibacterium acnes, and perifollicular inflammation, but reports no new clinical findings.